8 citations
,
August 2020 in “International Journal of Molecular Sciences” This study found that in Arabidopsis root hairs, oscillating cytoplasmic potassium dynamics precede growth oscillations, suggesting a complex interplay with calcium signaling and microfilament structure in regulating root hair growth.
2 citations
,
January 2014 in “Case Reports in Clinical Medicine” This case study presents an 81-year-old woman diagnosed with Cronkhite-Canada syndrome and discusses the importance of recognizing its clinical and histopathological features for timely and accurate diagnosis.
99 citations
,
January 2004 in “Progress in brain research” This review examines the role of neurotrophins in hair follicle development and remodeling, highlighting potential therapeutic applications for hair growth disorders, but it reports no new empirical findings.
70 citations
,
December 2004 in “Proceedings of the National Academy of Sciences” This study found that BMP signaling influences hair pigmentation in mice by affecting the Agouti protein and interacts with MC-1R pathways to modulate melanin production.
40 citations
,
November 2021 in “International Journal of Molecular Sciences” This review highlights the role of keratin mutations in epidermolysis bullosa simplex and the resulting chronic inflammation, but it presents no new experimental findings.
36 citations
,
June 2015 in “International journal of toxicology” This study established a new mouse model for TCE-induced skin sensitization and reported that proinflammatory cytokines TNF-α, IFN-γ, and IL-2 significantly contribute to this sensitization process.
17 citations
,
September 2020 in “Inflammation and Regeneration” In this study, researchers found that WNT activation influenced FGF expression in human scalp-derived fibroblasts, with mouse model results showing FGF9 increased hair follicle number and diameter, while FGF7 reduced diameter.
15 citations
,
May 2022 in “Journal of Investigative Dermatology” This study found that endothelial TLR2 is crucial for effective angiogenesis and timely wound healing, whereas TLR2 in hair follicle stem cells is not essential for skin regeneration.
14 citations
,
January 2021 in “Stem cell research & therapy” This study suggests that interfollicular epidermal keratinocytes with stem-like features may serve as an alternative to follicular keratinocytes for hair regeneration by supporting hair follicle morphogenesis in vivo.
12 citations
,
May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that disrupting Lm332 expression in mice changes keratinocyte genetic expression, alters cell shape, and disrupts epidermal homeostasis, despite some compensatory anchorage by hair follicle basal cells.
11 citations
,
March 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that hair loss in an Olmsted syndrome mouse model with a Trpv3 mutation was linked to premature keratinocyte maturation, affecting hair follicle structure and function.
8 citations
,
August 2023 in “Journal of Investigative Dermatology” This study reported that in a mouse tail wound model, the synthetic dual inhibitor corin accelerated wound closure by enhancing re-epithelialization, and further in vitro experiments demonstrated increased expression of genes promoting keratinocyte migration, suggesting its potential as a treatment for chronic wounds.
6 citations
,
August 2023 in “Journal of Investigative Dermatology” This study investigated how keratinocytes in the skin respond to different iron levels and found they play a significant role in regulating iron homeostasis by storing iron, affecting epidermal differentiation, and influencing inflammation-related gene expression in mice.
6 citations
,
April 2019 in “Nutrients” This study found that biotin deficiency in mice led to reduced zinc levels, disappearance of epidermal Langerhans cells, and increased ATP production, resulting in prolonged irritant contact dermatitis.
5 citations
,
April 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This article discusses junctional epidermolysis bullosa caused by COL17 deficiency, noting a lack of experimental therapies and the impact of nonsense mutations, but it reports no new clinical results.
5 citations
,
November 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that inhibiting Wnt/β-catenin signaling disrupted hemidesmosome organization in keratinocytes, suggesting potential therapeutic targets for HD-defective diseases like epidermolysis bullosa.
4 citations
,
May 2025 in “Life” This review highlights advancements in 3D bioprinting for skin tissue engineering, focusing on exosome-loaded bioinks that show potential for enhancing skin regeneration and repair.
3 citations
,
March 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This review explores the advantages and limitations of using zebrafish models to study various skin diseases, but reports no new experimental results.
3 citations
,
September 2021 in “BioEssays” This article discusses a novel hypothesis on the role of hair follicles in dandruff pathogenesis, focusing on immune response and inflammation due to scalp microbiota changes and sebum by-products, but reports no new clinical results.
2 citations
,
December 2025 in “Gels” This study developed a biomimetic 3D skin model with vascularization potential to assess the impact of nano-zinc oxide (nano-ZnO), finding that nano-ZnO significantly influenced genes related to apoptosis, inflammation, and oxidative stress in skin cells.
2 citations
,
October 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Aire‒/‒ mice spontaneously developed persistent AA-like lesions, highlighting a potential role for AIRE in hair follicle biology and pathogenesis of alopecia areata.
1 citations
,
December 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses various methods for processing and separating human skin samples for research purposes, evaluating factors like processing time and cell viability, but reports no new experimental findings.
1 citations
,
April 2016 in “Journal of lipid research” This study suggests that lipin-1 plays a crucial role in keratinocyte differentiation by modulating protein kinase C activity through diacylglycerol levels, with implications for skin biology.
September 2024 in “Journal of the American Academy of Dermatology” In this study, DataDerm revealed that from 2016 to 2022, a majority of patients diagnosed with keratinocyte carcinoma were male, predominantly white, and commonly between 56-75 years old, with most living in urban areas and having a history of non-melanoma skin cancer.
August 2021 in “Journal of Investigative Dermatology” In this study, Rahim et al. found that keratinocyte differentiation requires changes in polyamine ratios mediated by AMD1, suggesting that targeting polyamine availability could be useful for treating hyperproliferative skin disorders.
July 2019 in “Cancer Research” This study found that bone marrow-derived epithelial cells were abundantly recruited to some skin tumors in mice, indicating a systemic contribution to cutaneous neoplasms.
July 2019 in “Tumor Biology” In this study, researchers found that bone marrow-derived epithelial cells significantly contribute to the development of cutaneous tumors and dysplastic ulcers in mice, indicating a potential systemic role in skin cancer development.
April 2010 in “Cancer Research” This study suggests that Mcl-1 has a non-apoptotic role in promoting keratinocyte proliferation and Wnt/β-catenin signaling, potentially indicating a novel oncogenic activity.
38 citations
,
October 2001 in “British Journal of Dermatology” This study identified a new keratin, K6irs, as a potential histological marker for the inner root sheath of hair follicles in mice and humans, and as a candidate gene for hereditary hair defects.
16 citations
,
January 2023 in “Acta Biomaterialia” This study reported that a new bioinspired injectable hydrogel, CQCS@gel, showed promise as a multifunctional wound dressing by achieving rapid hemostasis and promoting the healing of infected skin wounds in both in vitro and in vivo tests.