Chronic Inflammation-Mediated Contribution of Bone Marrow-Derived Epithelial Cells and Hair Follicle Stem Cells to Development of Cutaneous Neoplasms

    July 2019 in “ Tumor Biology ”
    Heuijoon Park, Sonali Lad, Kelsey Boland, Kelly Johnson, Nyssa Readio, Guangchun Jin, Samuel A sfaha, Kelly S. Patterson, Ashok Singh, Xiangdong Yang, Douglas Londoño, Anupama Singh, Carol S. Trempus, Derek Gordon, Timothy C. Wang, Rebecca Morris
    TLDR Bone marrow-derived cells contribute to skin tumors, suggesting new treatment targets for non-melanoma skin cancers.
    The study investigated the role of bone marrow-derived epithelial cells (BMDECs) in the development of skin tumors in mice, using a model of chronic inflammation and carcinogenesis. It was found that BMDECs were recruited in significant numbers to over 40% of papillomas, contributing to the lesions alongside hair follicle stem cells. These cells were shown to proliferate and stratify within the epithelial tissue, and their recruitment was enhanced in dysplastic ulcers. The study also demonstrated that bone marrow cells could initiate benign and malignant lesions when exposed to carcinogens. These findings suggested a systemic contribution of BMDECs to skin neoplasms, highlighting potential new targets for treating non-melanoma skin cancers.
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