Abstract 5202: Bone Marrow-Derived Epithelial Cells Contribute to Chronic Skin Inflammation and Skin Tumor Formation in the Mouse

This study demonstrated that bone marrow-derived cells (BMDCs) contributed to skin tumor development and chronic skin inflammation in a mouse model. Researchers found that BMDCs were present in 37.78% of papilloma samples and 53.06% of ulcer-associated dysplastic skin samples, indicating their role as a new source of epithelial cells in damaged skin. These cells were primarily located in the basal epithelium and were highly proliferative, as shown by BrdU incorporation and Ki67 expression. The findings suggested that BMDCs could be an exogenous source of epithelial cells in skin lesions, including papillomas and ulcers, following bone marrow transplantation.