Abstract 5202: Bone Marrow-Derived Epithelial Cells Contribute to Chronic Skin Inflammation and Skin Tumor Formation in the Mouse

April 2012 in “ Cancer Research ”

Heuijoon Park, Nyssa Readio, Guang Jin, Samuel Asfaha, Anupama Singh, Ashok Singh, Xiangdong Yang, Kelly S. Patterson, Carol S. Trempus, Timothy C. Wang, Rebecca Morris

bone marrow-derived cells chronic skin inflammation skin tumor epithelial cells papilloma ulcer-associated dysplastic skin basal epithelium BrdU incorporation Ki67 expression skin tumorigenesis

TLDR Bone marrow-derived cells can lead to skin inflammation and tumors in mice.

This study demonstrated that bone marrow-derived cells (BMDCs) contributed to skin tumor development and chronic skin inflammation in a mouse model. Researchers found that BMDCs were present in 37.78% of papilloma samples and 53.06% of ulcer-associated dysplastic skin samples, indicating their role as a new source of epithelial cells in damaged skin. These cells were primarily located in the basal epithelium and were highly proliferative, as shown by BrdU incorporation and Ki67 expression. The findings suggested that BMDCs could be an exogenous source of epithelial cells in skin lesions, including papillomas and ulcers, following bone marrow transplantation.

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research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

Keratin K14 expression varies between hair follicles and epidermis, affecting cell differentiation.