Chronic Inflammation-Mediated Contribution of Bone Marrow-Derived Epithelial Cells and Hair Follicle Stem Cells to Development of Cutaneous Neoplasms

    July 2019 in “ Cancer Research ”
    Heuijoon Park, Sonali Lad, Kelsey Boland, Kelly Johnson, Nyssa Readio, Guangchun Jin, Samuel A sfaha, Kelly S. Patterson, Ashok Singh, Xiangdong Yang, Douglas Londoño, Anupama Singh, Carol S. Trempus, Derek Gordon, Timothy C. Wang, Rebecca Morris
    TLDR Bone marrow and hair follicle cells help form skin tumors, suggesting new treatment targets.
    The study investigated the role of bone marrow-derived epithelial cells (BMDECs) in the development of skin tumors in mice, using a model of chronic inflammation and carcinogenesis. It was found that BMDECs were recruited to over 40% of papillomas, occupying significant portions of the epithelial lesional area, and their recruitment was even greater in dysplastic ulcers. These cells contributed to lesions similarly to hair follicle stem cells. The study also demonstrated that bone marrow cells (BMCs) could initiate benign and malignant lesions when exposed to carcinogens, suggesting a systemic contribution to skin neoplasms. These findings highlighted the potential of targeting BMDECs for treating non-melanoma skin cancers and possibly other cancers.
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