Chronic Inflammation-Mediated Contribution of Bone Marrow-Derived Epithelial Cells and Hair Follicle Stem Cells to Development of Cutaneous Neoplasms

July 2019 in “ Cancer Research ”

Heuijoon Park, Sonali Lad, Kelsey Boland, Kelly Johnson, Nyssa Readio, Guangchun Jin, Samuel A sfaha, Kelly S. Patterson, Ashok Singh, Xiangdong Yang, Douglas Londoño, Anupama Singh, Carol S. Trempus, Derek Gordon, Timothy C. Wang, Rebecca Morris

chronic inflammation bone marrow-derived epithelial cells BMDECs hair follicle stem cells cutaneous neoplasms skin tumors papillomas dysplastic ulcers carcinogenesis lesions non-melanoma skin cancers skin cancer skin lesions

Studysummary This study found that bone marrow-derived epithelial cells were abundantly recruited to some skin tumors in mice, indicating a systemic contribution to cutaneous neoplasms.

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