research Potassium Channel Therapeutics at the Bedside
Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.
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research Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil
One minoxidil-sensitive potassium channel exists in human hair follicles.
research Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells
Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.
research Potassium Channel Openers: Pharmacological and Clinical Aspects
Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.
research Potassium Channel Openers: Therapeutic Potential in Cardiology and Medicine
Potassium channel openers show promise for treating heart disease and other conditions, but more research is needed to fully understand their effects and safety.
research Comparison of the Effects of the K+-Channel Openers Cromakalim and Minoxidil Sulphate on Vascular Smooth Muscle
Cromakalim relaxes various blood vessels, while minoxidil sulphate is more selective; they likely act on different potassium channels.
research Differential Inhibition by Tedisamil and Glibenclamide of the Responses to Cromakalim and Minoxidil Sulphate in Rat Isolated Aorta
Tedisamil and glibenclamide affect cromakalim and minoxidil sulphate differently in rat aorta.
research The Pharmacologic Basis of the Cardiovascular Toxicity of Minoxidil in the Dog
Minoxidil can harm dog's heart.
research Minoxidil Stimulates Elastin Expression in Aortic Smooth Muscle Cells
research Diagnostic Approach to Low-Renin Hypertension
Recent genetic insights show that low-renin hypertension includes a range from essential hypertension to secondary or familial forms, affecting diagnosis and treatment.
research Drug Repositioning Using In Silico Compound Profiling
Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.
research Immunohistochemical, Pharmacovigilance, and Omics Analyses Reveal the Involvement of ATP-Sensitive K+ Channel Subunits in Cancers: Role in Drug-Disease Interactions
ATP-sensitive K+ channel subunits, particularly Sur2A, play a significant role in various cancers.
research Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Regeneration After Facial Nerve Injury
Deleting the PTEN gene in mice causes nerve cells to grow larger and heal better after injury, but may cause overgrowth and hair loss in older mice.
research Minoxidil May Suppress Androgen Receptor-Related Functions
Minoxidil can reduce functions related to androgen receptors.
research 5-Alpha-Reductase Inhibitors Are Associated With Reduced Frequency of COVID-19 Symptoms in Males With Androgenetic Alopecia
5-alpha-reductase inhibitors may reduce COVID-19 symptoms in bald males.
research Clinical Symptoms of Hyperandrogenic Women Diagnosed with COVID-19
Women with high androgen levels may have more severe COVID-19 symptoms.
research K ATP Channels and Cardiovascular Disease
K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.
research A Comparative Study of Minoxidil-Induced Myocardial Lesions in Beagle Dogs and Miniature Swine
A study found that minoxidil can damage the hearts of dogs and pigs, cautioning its use in humans.
research Skin Conditions in Figure Skaters, Ice-Hockey Players, and Speed Skaters
Ice-skating athletes often have skin problems due to cold, infections, and inflammation, needing careful treatment and prevention.
research The Necessity of Investigations to Clarify Sex and Racial Disparities in Pathophysiology of Long COVID
More research is needed to understand sex and racial differences in long COVID.
research State-Dependent Signaling by Cav1.2 Regulates Hair Follicle Stem Cell Function
Cav1.2 affects hair growth and could be a target for hair loss treatments.
research Hypertension: Sex-Related Differences in Drug Treatment, Prevalence and Blood Pressure Control in Primary Care
Women experience more side effects and have worse blood pressure control from hypertension treatments than men, despite using different medications.
research Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism
Certain drugs increase calcium levels in cancer cells by triggering internal calcium release.
research Adverse Effects of Common Medications on Male Fertility
Some common medications can harm male fertility, but many effects can be reversed.
research Calcium Channel Inhibitor and Extracellular Calcium Improve Aminoglycoside-Induced Hair Cell Loss in Zebrafish
Certain substances can protect against ear damage from some antibiotics in zebrafish.
research Analysis of Post-COVID Symptoms and Predisposing Factors for Chronic Post-COVID Syndrome
Many COVID-19 patients have long-term symptoms, especially women, but certain medications may help reduce these symptoms.
research Repurposing of Approved Cardiovascular Drugs
Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.
research Effects of Nitrendipine, Nifedipine, Verapamil, Phentolamine, Papaverine, and Minoxidil on Contractions of Isolated Rabbit Aortic Smooth Muscle
Nitrendipine and nifedipine effectively block muscle contractions, while papaverine relaxes them and minoxidil needs high amounts to work.
research Pharmacologic Management of Acute Attacks of Migraine and Prevention of Migraine Headache
Use NSAIDs for immediate migraine relief and β-blockers for prevention; tailor treatment to the individual.
research Safety of Antiandrogens for the Treatment of Female Androgenetic Alopecia with Respect to Gynecologic Malignancies
Spironolactone is safe for treating female hair loss, but the safety of other drugs is uncertain.