Differential Inhibition by Tedisamil and Glibenclamide of the Responses to Cromakalim and Minoxidil Sulphate in Rat Isolated Aorta

The study investigated the effects of tedisamil and glibenclamide on the responses to cromakalim and minoxidil sulphate in rat isolated aorta. The results showed that tedisamil and glibenclamide had similar potency in inhibiting the K+ efflux induced by cromakalim and minoxidil sulphate. However, glibenclamide was more effective in inhibiting the vasorelaxations induced by the two K+ channel openers compared to tedisamil. The study suggests that cromakalim and minoxidil sulphate may possess additional actions that are inhibited by glibenclamide but not tedisamil. The mechanisms of these effects remain to be elucidated.