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Environmental cues can change the fate and function of epithelial cells, with potential for cell therapy.

The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.

KIF18B is important for correctly positioning cell division machinery in skin cells, affecting hair follicle development.

Lymphoid-specific helicase (Lsh) is crucial for skin growth, change, and healing after injury.

Most vertebrates can regenerate skin, nails, and corneas, but only some can regenerate teeth and lenses.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

When skin blisters, healing the wound is more important than growing hair, and certain stem cells mainly fix the blisters without helping hair growth.

Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.

Aging reduces skin stem cell function, leading to changes like hair loss and slower wound healing.

Hemoglobin α acts as an antioxidant in skin cells, especially protecting hair follicle stem cells from UV damage.

Notch signalling helps skin cells differentiate and prevents tumors.

Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

Thyrotropin-releasing hormone may help control skin and hair growth and could aid in treating related disorders.

Activating TERT in mice skin boosts hair growth by waking up hair follicle stem cells.

Bioengineering can potentially treat hair loss by regenerating hair follicles and cloning hair, but the process is complex and needs more research.

Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.

Hair follicles help skin immune recovery after UVB exposure.

c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.

The risk of skin tumors becoming malignant depends on the specific skin cell type affected.

Sox21 is crucial for tooth development and enamel formation by preventing cells from changing into a different type.

Retinoic acid helps change skin cells and is important for skin development and hair growth.

Melanocyte stem cells are crucial for skin pigmentation and have potential in disease modeling and regenerative medicine.

Hair keratins evolved from ancient proteins, diversifying through gene changes, crucial for forming claws and later hair in mammals.

Conditioned medium from keratinocytes can improve hair growth potential in cultured dermal papilla cells.

Wnt signaling is crucial for skin development and hair growth.

Vitamin D receptor is crucial for skin wound healing.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

Vitamin D compounds may help treat psoriasis by promoting skin cell differentiation.