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    Glossary Innate Immune Cells

    cells that provide immediate, non-specific defense against pathogens

    Innate immune cells are a type of immune cell that form the body's first line of defense against infections. These cells, which include macrophages, neutrophils, and natural killer (NK) cells, respond quickly to pathogens in a non-specific manner, meaning they attack any foreign invader without needing prior exposure. They are crucial for immediate defense and also help to activate the adaptive immune system for a more targeted response.

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    1. Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells Journal of immunology research · 2019 · 47 citations
    2. Hidradenitis suppurativa: A folliculotropic disease of innate immune barrier dysfunction? Experimental dermatology · 2021 · 9 citations
    3. Squaric Acid Dibutylester Promotes Innate Immune-Driven Hair Growth with CD206+ Macrophage Accumulation in the Dermis JID Innovations · 2025
    4. 440 Squaric acid dibutylester, used in alopecia areata immunotherapy, promotes innate immune-driven hair growth with CD206+ macrophage accumulation in the dermis Journal of Investigative Dermatology · 2024
    5. A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    6. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium Cell · 2019 · 181 citations
    7. Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models International Journal of Molecular Sciences · 2022 · 5 citations
    8. Innate lymphoid cells type 1 may be new, non-antigen-specific player in the pathogenesis of alopecia areata 2019
    9. 431 Innate lymphoid cells type 1 may be new, non-antigen-specific player in the pathogenesis of alopecia areata Journal of Investigative Dermatology · 2019
    10. Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis Nature Communications · 2026
    11. Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta Immunity · 2018 · 96 citations
    12. Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair Nature Communications · 2016 · 86 citations
    13. Dissecting the Roles of Innate Cells in the Skin and Intractable Skin Diseases The Keio Journal of Medicine · 2022 · 1 citations
    14. Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia PLOS ONE · 2012 · 22 citations
    15. 0150 Single-cell and spatial transcriptome profiling reveals innate-adaptive crosstalk in alopecia areata Journal of Investigative Dermatology · 2025
    16. Understanding Type 3 Innate Lymphoid Cells and Crosstalk with the Microbiota: A Skin Connection International journal of molecular sciences · 2024
    17. Jagged-1+ Skin Tregs Modulate the Innate Immune Response to Wound Healing Research Square (Research Square) · 2024
    18. New insights into inflammatory memory of epidermal stem cells Frontiers in immunology · 2023 · 2 citations
    19. Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia Research Square (Research Square) · 2023
    20. Pro-inflammatory Vδ1+T-cells infiltrates are present in and around the hair bulbs of non-lesional and lesional alopecia areata hair follicles Journal of Dermatological Science · 2020 · 23 citations
    21. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity Nature · 2010 · 717 citations
    22. Trained Immunity and Local Innate Immune Memory in the Lung Cell · 2018 · 77 citations
    23. <i>Urticaria Neonatorum:</i> Accumulation of tryptase‐expressing mast cells in the skin lesions of newborns with Erythema Toxicum Pediatric allergy and immunology · 2007 · 14 citations
    24. The developing immune network in human prenatal skin Immunology · 2020 · 11 citations
    25. Resident Memory T Cells in Autoimmune Skin Diseases Frontiers in immunology · 2021 · 50 citations
    26. 332 OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity Journal of Investigative Dermatology · 2022
    27. Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata bioRxiv (Cold Spring Harbor Laboratory) · 2022
    28. LB708 ILC1-like innate lymphocytes in human autoimmunity: Lessons from Alopecia Areata Journal of Investigative Dermatology · 2021
    29. Merkel cell polyomavirus infection and persistence modelled in skin organoids 2025 · 2 citations
    30. Cell‐free DNA is elevated in the serum of patients with hidradenitis suppurativa The Journal of Dermatology · 2022 · 2 citations