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Computational methods can speed up and improve the development and safety of herbal drugs.

α3β1-integrin is crucial for maintaining normal hair follicle shape and function but not needed for the development of the surrounding skin.

The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Using steroids can increase the risk of heart problems.

Androgens can both increase and decrease hair growth in different parts of the body.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Cornification is the process where living skin cells die to create a protective barrier, and problems with it can cause skin diseases.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Apigenin may help promote hair growth and could treat hair loss.

Alternative treatments show promise for hair growth beyond traditional methods.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Chemotherapy often causes temporary hair loss, which is distressing and needs better treatment and support.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Prolactin affects hair growth cycles and can cause early hair follicle regression.

A certain smell receptor in hair follicles can affect hair growth when activated by a synthetic sandalwood scent.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

TGF-β2 plays a key role in human hair growth and development.

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

Genomic approach finds new possible treatments for hair loss.

Human hair grows better in a special gel that mimics skin.

Compounds from certain trees used by First Nations people show potential for treating skin conditions and promoting hair growth, but more research is needed to confirm their safety and effectiveness.

Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.

The document concludes that permanent hair loss conditions are complex, require early specific treatments, and "secondary permanent alopecias" might be a more accurate term than "secondary cicatricial alopecia."

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

ALA-PDT is effective and safe for chronic X-ray dermatitis, providing complete or partial remission.

Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.

Blocking interferon-gamma might help treat various autoimmune diseases.