Botanicals With Dermatologic Properties Derived From First Nations Healing: Part 1—Trees

The article from 2017 reviewed the dermatologic properties of compounds derived from five trees traditionally used by First Nations people, focusing on their potential in treating various skin conditions and promoting hair growth. Western red cedar's ß-thujaplicin was noted for its promise in treating atopic dermatitis and hair growth, while white spruce's compound showed anti-inflammatory properties. Birch bark emulsion was in phase II clinical trials for several skin conditions, and balsam poplar was recognized for anti-aging, with black spruce bark containing antioxidant trans-resveratrol. Betulin and betulinic acid, particularly from birch, demonstrated a range of activities against skin conditions and pathogens, with clinical studies showing promising results, such as a significant reduction in actinic keratoses with birch bark ointment. However, the document highlighted the need for more clinical trials to establish the safety and efficacy of these botanicals in dermatology.