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PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

Self-amplifying RNA could be a better option for protein replacement therapy with lower doses and lasting effects, but delivering it into cells is still challenging.

Solidified SEDDS improve drug stability and bioavailability better than liquid SEDDS.

Mesenchymal stem cells could help treat aging-related diseases better than current methods.

Hibiscus anthocyanins help protect the liver and improve antioxidants in diabetic rats.

Yellow Chinese chive extract helps protect mouse livers from damage caused by acetaminophen by activating an antioxidant pathway.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Finasteride and methadone don't increase advanced liver disease risk in HCV+ male veterans.

Acne is caused by increased sebum, abnormal skin shedding, bacteria, and inflammation, not dirt; treatments vary from creams to antibiotics or isotretinoin, with severe cases needing a dermatologist's care.

Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.

Low zinc levels in chronic liver disease patients are linked to more severe symptoms like taste issues and skin problems, and zinc supplements might help.

Cytochrome P-450 enzymes in the skin help break down various substances and could be targeted to treat skin conditions.

Finasteride in male rats causes liver and metabolic issues in their offspring.

Chromosomal differences affect how muscle cells respond to testosterone.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Low and ultralow doses of flutamide can cause liver damage in young women with high androgen levels, regardless of dose or birth control use, with higher risk for those with higher BMI and liver enzyme levels before treatment.

Finasteride affects brain stress and enzyme activity differently in various regions, possibly helping with liver-related brain issues.

Substance abuse can cause various skin problems, including marks from injections, sores, premature aging, and increased cancer risk.

Women with PCOS face many health risks, but exercise, a healthy diet, and weight management can help.

Trichohyalin is modified by enzymes to form strong structures in hair cells.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Rutin may help treat symptoms of polycystic ovary syndrome (PCOS) in rats.

PCOS in lean women is a serious health condition with implications beyond fertility, affecting metabolism and increasing cardiovascular disease risk.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.