Finasteride and Methadone Use and Risk of Advanced Hepatitis C Related Liver Disease

June 2012 in “ Digestive Diseases and Sciences ”

Donna L. White, Ali Madeeh Hashmi, David Ramsey, Jill Kuzniarek, Shahriar Tavakoli-Tabasi, Hashem B. El-Serag

TLDR Finasteride and methadone don't increase advanced liver disease risk in HCV+ male veterans.

The study aimed to investigate whether the use of finasteride for BPH and methadone for opiate addiction is associated with an increased risk of advanced hepatic fibrosis and inflammatory activity in HCV+ male veterans. The study recruited 571 male veterans with chronic HCV not receiving antiviral therapy at their scheduled primary care visit. The results showed that there was no significant association between the use of finasteride or methadone and the risk of advanced HCV-related liver disease. The study concluded that the use of finasteride or methadone does not increase the risk of advanced hepatic fibrosis or inflammatory activity in HCV+ male veterans.

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