January 2013 in “China Animal Husbandry & Veterinary Medicine” This study found that IGFBP-5 may play a significant regulatory role in the hair follicle development of Inner Mongolia Cashmere goats, with more consistent expression patterns across different stages.
2 citations
,
May 2025 in “PLoS ONE” This study found that a 4:1 combination of Rhynchosia nulubilis and Polygonum multiflorum extracts significantly promoted the proliferation of human dermal papilla cells and alleviated testosterone-induced cytotoxicity, suggesting potential for treating hair loss and related disorders through a synergistic approach.
9 citations
,
January 2023 in “Cellular and Molecular Life Sciences” This study found that intrauterine administration of botulinum toxin A improved endometrial environment and receptivity in a murine model of thin endometrium through mechanisms involving IGFBP3 and osteopontin.
37 citations
,
June 1996 in “Journal of cellular physiology” This study found that IGF1, retinoic acid, and dexamethasone increase IGFBP-3 production in cultured human dermal papilla cells, potentially inhibiting IGF1 action on hair growth.
26 citations
,
June 2000 in “Journal of The American Academy of Dermatology” This study found that older men with vertex balding had lower levels of IGFBP-3 and higher levels of IGF-1 in their plasma.
3 citations
,
June 2000 in “Journal of The American Academy of Dermatology” This study found that older men with vertex balding have lower circulating levels of the protein IGFBP-3 and higher levels of IGF-1.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that women with female pattern hair loss had significantly lower serum IGF-1 levels than controls, suggesting a possible role for IGF-1 in this condition.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that women with female pattern hair loss had significantly lower serum IGF-1 levels compared to controls, but no significant association between IGFBP-3 levels and hair loss severity was observed.
March 2026 in “European Journal of Medical and Health Research” In this case-control study, researchers observed that women with female pattern hair loss exhibited significantly lower serum IGF-1 levels than controls, while IGFBP-3 levels showed no significant difference, suggesting a potential role for IGF-1 in the condition.
July 2024 in “Experimental Dermatology” This study suggests that APC collagen peptides may accelerate hair growth and promote overall hair health by enhancing cellular proliferation and activating specific signaling pathways in human and mouse models.
7 citations
,
January 2023 in “Journal of Animal Science” This study found that the miRNA chi-miR-877-3p affects hair follicle cycles in Jiangnan cashmere goats by regulating IGFBP5 gene expression and cell proliferation.
25 citations
,
December 2008 in “The Journal of Urology” In this study, short-term finasteride treatment reduced apoptotic factors caspase-7 and IGFBP-3 in prostate cancer cells but did not significantly affect androgen receptor expression compared to placebo.
April 2003 in “Experimental Dermatology” This workshop review from the Australian Hair and Wool Research Society discusses findings in cutaneous biology and endocrinology but presents no new research results.
44 citations
,
April 2012 in “BMB Reports” This study identified several DPC-specific proteins, including ITGB1, IGFBP3, and THBS1, as potential biomarkers for hair growth modulation through proteomic and network analysis.
6 citations
,
March 2024 in “Journal of Clinical Laboratory Analysis” This study reported that IGF2BP2 rs1470579 and IGFBP3 rs2854744 may increase the risk of polycystic ovary syndrome in a Southeastern Iranian population.
2 citations
,
August 2023 in “The Journal of Animal and Plant Sciences” This study identified 1277 genomic regions selected for traits in indigenous Chinese goats, including cashmere fiber, reproduction, size, and high-altitude adaptation, revealing key candidate genes for these phenotypes through whole-genome resequencing.
July 2025 in “Journal of Investigative Dermatology” Secreted inhibitors of Wnt and IGF signaling control hair and tooth development, creating species-specific patterns.
20 citations
,
December 2020 in “Frontiers in Immunology” This study found that certain T cell-associated genes were upregulated in dogs with Vogt-Koyanagi-Harada syndrome and vitiligo, suggesting a shared immunopathogenesis with humans.
8 citations
,
January 2024 in “Medical Principles and Practice” This study found that silencing IGFBP5 reduced neurotoxicity and motor deficits in the 6-OHDA model of Parkinson's disease, likely by affecting the SHH signaling pathway, suggesting its potential role in mitigating Parkinson’s-related neuronal damage.
77 citations
,
March 2004 in “Human Reproduction” This study found that women with symptoms of oligomenorrhoea and/or hirsutism are more likely to have polycystic ovaries and less favorable biochemical and clinical markers compared to asymptomatic women.
134 citations
,
January 2010 in “Biomedical research” This study found that subcutaneous administration of conditioned medium from adipose-derived stem cells promoted hair growth in mice, and hypoxia enhanced this effect by altering growth factor secretion.
17 citations
,
February 2015 in “International Journal of Molecular Sciences” This study found that keratinocyte stem/progenitor cell-conditioned medium significantly enhanced hair growth in mice and increased the proliferation of human hair follicle cells.
21 citations
,
September 2010 in “Cancer Prevention Research” This study suggests that IGFBP-2 may play a role in basal cell carcinoma development by mediating epidermal progenitor cell expansion in hair follicles with activated Shh signaling.
5 citations
,
September 2010 in “Cancer Prevention Research” This perspective discusses Villani et al.'s findings on the role of the IGF regulatory protein Igfbp2 in basal cell carcinogenesis and highlights potential therapeutic and preventive targets, while raising questions about the cell of origin.
46 citations
,
August 2006 in “Mechanisms of Development” Runx1 is crucial for proper hair structure and development.
August 2026 in “Frontiers in Veterinary Science” This study identified 22 genetic loci potentially linked to body weight and wool traits in Ordos fine-wool sheep, highlighting six candidate genes that could be pivotal in understanding and improving these economically important characteristics.
21 citations
,
January 2018 in “The Korean Journal of Physiology and Pharmacology” This study found that human umbilical cord blood mesenchymal stem cells promoted hair growth by advancing anagen onset and increasing hair follicle regeneration in an in vivo model.
20 citations
,
January 2019 in “Journal of dermatological science” This study suggests that androgens enhance growth factor production in dermal fibroblasts, which in turn may alter keratinocyte differentiation and contribute to acne lesion formation.
5 citations
,
September 2019 in “ACS Applied Bio Materials” This study developed a composite hydrogel that delivered multiple proteins, enhancing skin wound healing by accelerating closure and promoting hair follicle regeneration.
5 citations
,
February 2019 in “PloS one” This study found that structural defects in the hair shafts of sighthounds with bald thigh syndrome are related to a downregulation of genes and proteins essential for hair shaft formation.