Intrauterine Botulinum Toxin A Administration Promotes Endometrial Regeneration Mediated by IGFBP3-Dependent OPN Proteolytic Cleavage in Thin Endometrium

This study investigates the effects of intrauterine botulinum toxin A (BoTA) on endometrial regeneration in a murine model of thin endometrium. The research found that BoTA administration significantly improved endometrial thickness and embryo implantation rates by restoring the expressions of insulin-like growth factor binding protein-3 (IGFBP3) and an active form of osteopontin (OPN). The study suggests that BoTA promotes endometrial regeneration through IGFBP3-dependent OPN proteolytic cleavage, enhancing endometrial receptivity and angiogenesis. These findings propose BoTA as a potential therapeutic strategy for patients with thin endometrium.