57 citations
,
May 1986 in “Clinics in endocrinology and metabolism” This review found that women with idiopathic hirsutism may have increased 5α-reductase activity, as indicated by elevated levels of a dihydrotestosterone-reduced metabolite, but more research is needed to confirm its clinical relevance as a biomarker.
26 citations
,
January 2020 in “Przegląd Menopauzalny” This review discusses the role of androgens in menopausal women's health, highlighting symptoms of both hyperandrogenemia and androgen deficiency, but reports no clinical results.
29 citations
,
October 2020 in “Journal of the European Academy of Dermatology and Venereology” This article is a discussion piece that examines the clinical symptoms of hyperandrogenic women with COVID-19, without reporting new research findings.
January 2025 in “Journal of Clinical Medicine” This study found that among Portuguese women with hirsutism, polycystic ovary syndrome was the most prevalent cause, associated with distinct hormonal features and higher BMI compared to controls.
September 2021 in “Conference Proceedings” This study observed that hyperandrogenism in men manifests with varying symptoms, where older men may have high total testosterone due to increased SHBG without elevated free testosterone, while younger men often show signs like acne and alopecia with elevated DHT or testosterone.
1 citations
,
January 2021 in “Prague medical report” This article reviews the potential male equivalent of polycystic ovarian syndrome, focusing on hormonal alterations and premature androgenic alopecia, but reports no new clinical findings; the authors highlight the need for further studies on adrenal steroids and other factors.
June 2020 in “ACTA MEDICA IRANICA” This case report describes a postmenopausal woman with virilization and an ovarian steroid cell tumor, highlighting the rarity and diagnostic importance of such tumors in this demographic.
April 2019 in “Journal of the Endocrine Society” In this case study, the researchers reported that treating a woman with type B insulin resistance using rituximab, dexamethasone, and cyclophosphamide greatly reduced her insulin needs, but her hyperandrogenic state persisted, suggesting ovarian hyperthecosis.
2 citations
,
January 2018 in “Sovremennye problemy nauki i obrazovaniâ” Hirsutism and acanthosis nigricans are important for diagnosing PCOS; dermatologists play a key role in early detection and treatment.
January 2021 in “Voprosy ginekologii akušerstva i perinatologii” In this article, the authors detail approaches for diagnosing and managing hyperandrogenism in young women, focusing on conditions like polycystic ovary syndrome and hirsutism, and highlight the importance of differentiating physiological from pathological causes to guide appropriate treatment strategies, often involving combined oral contraceptives.
23 citations
,
January 2016 in “Journal of Nanjing Medical University” This study found that higher BMI in PCOS patients at a Chinese clinic was associated with functional disorders of androgen excess, suggesting BMI may predict hyperandrogenism in this population.
8 citations
,
May 1991 in “PubMed” This case study from Boston University details a 35-year-old woman diagnosed with congenital adrenal hyperplasia, treated with dexamethasone, leading to normalized androgen levels and successful conception.
April 2026 in “Russian Journal of Skin and Venereal Diseases” This review reports that hyperandrogenic conditions in women, which affect skin and overall well-being, lack dedicated treatment guidelines, presenting challenges in standardizing care.
99 citations
,
August 2003 in “Fertility and Sterility” This paper discusses polycystic ovary syndrome with a focus on androgen excess as the primary symptom and notes that insulin resistance may contribute to it in many patients, but provides no new research findings.
8 citations
,
January 1986 in “Journal of hepatology” This study suggests that hepatocellular carcinoma in cirrhotic men is associated with altered sex-steroid metabolism, indicated by lower testosterone and 5 alpha-dihydrotestosterone levels compared to cirrhosis alone.
7 citations
,
January 2013 in “Hormone Research in Paediatrics” This case report describes an adult female with congenital adrenal hyperplasia who developed secondary amenorrhea and hair loss due to androgen overproduction from ovarian adrenal rests, detectable only after pelvic venous sampling, and normalizing after unilateral oophorectomy.
January 2022 in “Journal of Morphological Sciences” This case report presents a 60-year-old woman with virilization and elevated adrenal androgens, where a bilateral salpingo-oophorectomy confirmed ovarian steroid cell tumor NOS, and her symptoms resolved post-operatively.
2 citations
,
January 2005 in “PubMed” In this study, females with hirsutism showed higher levels of certain androgens and reported more frequent symptoms such as infertility and increased skin greasiness compared to those without hirsutism.
26 citations
,
January 2000 in “Hormone research in paediatrics” This review discusses the relationship between hyperandrogenism and insulin resistance in PCOS, focusing on insulin dynamics, molecular mechanisms, genetic studies, and potential long-term treatments, but presents no new clinical results.
May 2025 in “Journal of the ASEAN Federation of Endocrine Societies” This case study highlights a testosterone- and cortisol-secreting adrenal oncocytic neoplasm in an 18-year-old woman, illustrating the role of surgical excision in resolving hyperandrogenism and restoring menstruation.
October 2023 in “ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS” This study found that in women with PCOS, insulin resistance is closely associated with hyperandrogenism, indicating it may independently predict increased androgen levels.
1 citations
,
July 2024 in “Journal of Medical and Life Science” In this review, researchers examined the complex interaction of hormones, genes, and reactive oxygen species in hirsutism and PCOS, highlighting prolactin's role in modulating hormone levels linked to hair growth disorders.
26 citations
,
April 2007 in “Journal of pediatric gastroenterology and nutrition” This case report describes an adolescent girl with polycystic ovarian syndrome and endogenously elevated androgen levels who developed a hepatic adenoma, suggesting a link between the two conditions.
July 2023 in “Journal of the ASEAN Federation of Endocrine Societies” In this study of a postmenopausal woman with hyperandrogenism, GnRH agonist treatment significantly reduced testosterone levels, suggesting the androgen excess was ovarian in origin and indicating the potential of using GnRH agonists as a conservative treatment option when surgery is not feasible.
5 citations
,
January 2014 in “Postepy Dermatologii I Alergologii” Among women with hirsutism studied, this research found a high prevalence of acne, particularly associated with polycystic ovarian syndrome and endocrine changes.
May 2006 in “Women's Health Medicine” This review examines the causes, assessment, and treatments of hirsutism and highlights the need for future research in managing this condition but presents no new research findings.
May 2013 in “Journal of the ASEAN Federation of Endocrine Societies” This case study reports that a 61-year-old woman with high testosterone levels due to stromal luteoma of the left ovary experienced rapid normalization of testosterone levels after surgical removal of the tumor.
April 2024 in “Women s Health Reports” This study explored the clinical and biochemical hyperandrogenic status in adolescents with irregular menses to identify significant indicators of potential metabolic problems linked to PCOS.
January 1983 in “Elsevier eBooks” Masculinization in affected individuals occurs gradually after puberty due to hormone changes.
10 citations
,
January 2004 in “KARGER eBooks” This article reviews the differential diagnosis of mild hyperandrogenism in adolescent girls, discussing potential causes such as PCOS and nonclassic adrenal hyperplasia, but presents no new data.