Hyperandrogenism in Adolescent Girls: Diagnosis and Management

The document from 2004 examines the complexity of diagnosing hyperandrogenism and PCOS in adolescent girls, noting that symptoms like acne and irregular menstrual cycles can be common in puberty but may also indicate underlying conditions such as PCOS. It discusses the physiological changes during puberty, the clinical aspects of PCOS, and the challenges in using hormonal markers and ultrasound for diagnosis. The document also explores the differentiation between classic and non-classic forms of PCOS, the pathophysiology of non-classic adrenal hyperplasia (NCAH), and other causes of hyperandrogenism. Treatment options for PCOS include oral contraceptives, antiandrogens, and lifestyle changes, while NCAH is typically treated with glucocorticoids. The importance of considering the psychological impact of PCOS on adolescents is highlighted, along with the need for careful diagnosis and management.