24 citations
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March 2017 in “Archives of Gynecology and Obstetrics” The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.
June 2025 in “British Journal of Dermatology” This case study describes an uncommon variant of coudability hair in alopecia areata, where intermittent inflammatory processes result in alternating bands of lighter color and reduced hair shaft calibre.
August 2025 in “Figshare” This meta-analysis found that patients with alopecia areata, especially those with alopecia totalis or alopecia universalis, have an increased risk of cardiovascular disease, possibly due to shared immunological mechanisms and systemic inflammation. Further research is needed to confirm these findings and explore underlying mechanisms.
This study found that among women with polycystic ovary syndrome, higher age, obesity, hirsutism, and having children were independently associated with increased metabolic risk.
November 2021 in “European Heart Journal Supplements” In this case report, a 29-year-old woman with systemic lupus erythematosus and an increased risk of thrombosis experienced improved right heart function following diuretics, anticoagulants, corticosteroids, and immunosuppressants treatment.
September 2017 in “Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān” This study observed that individuals with androgenetic alopecia had abnormal correlations in hematologic parameters, suggesting a chronic, slowly progressing immune-related disorder tied to pubertal androgen secretion.
31 citations
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January 2016 in “Drugs - Real World Outcomes” This review discusses the potential link between direct oral anticoagulants and hair loss, suggesting DOACs may not be a suitable alternative for patients with alopecia from traditional anticoagulants; however, no clinical results are reported.
July 2024 in “The Journal of Dermatology” This article reported a case where a patient experienced both alopecia areata multiplex and chronic idiopathic thrombocytopenic purpura, an uncommon association, but it did not include specific results or detailed analyses.
November 2023 in “International Journal of Dermatology” In this study, CCCA patients were found to have higher odds of metabolic, autoimmune, atopic, and psychiatric comorbidities compared to matched controls.
39 citations
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November 2009 in “Clinical and Experimental Dermatology” This study reports that in primary cicatricial alopecias, increased expression of certain immune markers in the hair-follicle bulge suggests a collapse of immune privilege, which may contribute to follicle destruction.
41 citations
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January 2000 in “Hormone Research in Paediatrics” In this case study, a 55-year-old woman with androgenetic alopecia was ultimately diagnosed with hepatic cortisone reductase deficiency after initially suspected 21-hydroxylase deficiency was ruled out.
January 2014 in “International Journal of Clinical Medicine” This case report suggests that premature aging may contribute to weakened immunity and the development of autoimmune diseases.
8 citations
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January 1986 in “Journal of hepatology” This study suggests that hepatocellular carcinoma in cirrhotic men is associated with altered sex-steroid metabolism, indicated by lower testosterone and 5 alpha-dihydrotestosterone levels compared to cirrhosis alone.
September 2018 in “Fertility and Sterility” In this study, researchers observed that overweight Taiwanese women with PCOS who carry the HSD3B1 1245C allele have a significantly higher risk of developing androgenic alopecia compared to those with the wild-type allele.
August 2020 in “Benha Journal of Applied Sciences” This study found that patients with androgenetic alopecia had significantly higher mean platelet volume, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio compared to healthy controls.
87 citations
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May 2018 in “Scientific Reports” This study found that in healthy men, higher levels of free testosterone were associated with a stronger immune response to the influenza vaccine, suggesting androgens may function as immunomodulators rather than strict immunosuppressants.
3 citations
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October 2024 in “Experimental Dermatology” This study found that patients with alopecia areata exhibited increased CRHR1 expression on circulating monocytes compared to controls, suggesting that stress-related factors like CRH and CRHR1 may contribute to the development and progression of the condition, particularly in chronic cases and those with larger lesions.
7 citations
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October 2019 in “Clinical, Cosmetic and Investigational Dermatology” This study found that specific polymorphisms in the VDR gene, Taq1, and Cdx1, were significantly associated with increased risk of chronic telogen effluvium in women.
11 citations
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March 1991 in “PubMed” This study found that in female patients with androgenic hair loss and hirsutism, complex hormonal disturbances include elevated cortisol and thyroid hormone imbalances, rather than elevated androgen levels alone.
17 citations
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October 2020 in “South African Medical Journal” This review highlights that fungal co-infections, notably with Aspergillus and Candida, are common in hospitalized COVID-19 patients, but their impact on disease outcomes remains unclear, indicating a need for further research.
16 citations
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August 2002 in “Journal of Interferon and Cytokine Research” In this case study, hypertrichosis in a patient with hemophilia and hepatitis C may have been induced by IFN-alpha treatment, despite the drug usually causing hair loss.
March 2022 in “Evidence-based Complementary and Alternative Medicine” This study found that critically ill pulmonary patients with deficiency syndrome were at a higher risk of developing type 2 myocardial infarction than those with phlegm syndrome.
28 citations
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February 2011 in “Clinical Endocrinology” In this study, women with polycystic ovary syndrome showed adverse lipoprotein profile changes that increase cardiovascular risk, which were found to be more closely related to androgen levels than body weight.
10 citations
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October 1992 in “PubMed” This case study suggests that thrombosis was related to anti-phospholipid antibody in a woman with systemic lupus erythematosus, characterized by multiple aseptic bone necroses and arterial blockages.
21 citations
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March 2023 in “Journal of Crohn s and Colitis” This study suggests that microvascular damage and platelet deregulation may persist in ulcerative colitis patients even during remission, remaining as disease-associated molecular signatures.
26 citations
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August 2009 in “Journal of Pediatric Gastroenterology and Nutrition” This study reports that gastrointestinal problems, such as intractable diarrhea and enterocolitis, can dominate the clinical course of patients with Hoyeraal-Hreidarsson syndrome and may occur before hematological and immunological symptoms.
1 citations
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February 2025 in “Journal of the Neurological Sciences” This study suggests that BTP levels in cerebrospinal fluid might help diagnose CIDP and predict therapy response but require validation in larger cohorts.
4 citations
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December 2016 in “Blood” This study describes a case of cyclic thrombocytopenia where a novel MPL gene mutation may contribute to the disease, with gene expression changes in platelet and neutrophil genes preceding platelet count fluctuations.
January 2024 in “Indian Journal of Dermatology” This study found that women with FPHL may have an increased cardiovascular risk, as indicated by associations with metabolic syndrome, insulin resistance, and elevated biochemical markers.
May 2026 in “Russian Journal of Skin and Venereal Diseases” In this study, researchers observed a high prevalence of ferritin and vitamin D deficiency in women with acute telogen effluvium, highlighting the importance of laboratory screening for these deficiencies, while also noting a correlation between ferritin levels and hair loss severity.