Autoimmune Diseases and Acquired Von Willebrand Disease in Two Cases of Progeria

The document described two cases of progeria in a family, highlighting autoimmune complications. Ammar A., a 23-year-old male, exhibited growth retardation, early graying, alopecia, and skin changes from childhood. He developed a pulmonary infection and later a mucocutaneous bullous eruption, partially responsive to prednisolone. His sister, Qawthar A., showed similar symptoms, including vitiligo, hepatosplenomegaly, severe anemia, and jaundice, which improved with treatment. Ammar later presented with symptoms consistent with acquired Von Willebrand’s disease. The study concluded that premature aging predisposes individuals to disturbed immunity and autoimmune diseases.