3 citations
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March 2025 in “Arthritis Research & Therapy” This study found that combining high-density fat grafting with botulinum toxin A significantly improved symptoms of Raynaud’s phenomenon, including reducing pain and cold sensitivity, speeding up ulcer healing, and enhancing blood perfusion, compared to fat grafting alone.
April 2024 in “Asian Journal of Medical Sciences” This study found that ring block anesthesia was the most acceptable method for reducing pain during platelet-rich plasma injections for hair loss.
April 2017 in “Journal of Investigative Dermatology” In laboratory tests and mouse models, this study found that the novel IPC analog SIG-1451 may offer potent anti-inflammatory effects for treating allergic skin inflammation, potentially outperforming some current therapies in specific inflammatory phases.
This review discusses advances in understanding tickling sensations and proposes that knismesis hypersensitivity in autism spectrum disorder may be due to impaired sensory integration.
April 2022 in “Journal of The American Academy of Dermatology” This article discusses scalp neuropathy in androgenetic alopecia and suggests that changes in tactile sensation due to Aβ fibers and increased nociception from circ-HTMR may be involved.
August 2019 in “Journal of the American Academy of Dermatology” Older adults may experience painful finger pitting due to nerve changes in aging skin, and treatments can help reduce symptoms.
April 2023 in “IntechOpen eBooks” This review discusses neuropathic pruritus, detailing its clinical presentations and management strategies, but reports no new clinical results.
November 2025 in “Biomedicines” This study found that the JAK1 inhibitors baricitinib and abrocitinib significantly reduced mechanical alloknesis in a murine model of atopic dermatitis, whereas the JAK2 inhibitor AZ960 had no effect.
2 citations
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October 2020 in “Drug Discoveries & Therapeutics” This study observed that Althaea officinalis gel increased fibroblast populations, hair follicles, and vessel diameter in rat wounds, suggesting it might aid wound healing, though further clinical studies are needed.
6 citations
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December 2016 in “Journal of Obsessive-Compulsive and Related Disorders” This study found that adults with trichotillomania did not show differences in pain tolerance or exhibit analgesia to cold pressor pain compared to healthy controls.
January 2024 in “Wiadomości Lekarskie” This research by Dr. Lester Fehmi suggests that exercises to shift attention from focused to dispersed may enhance alpha wave synchronization in the brain, potentially reducing pain perception.
6 citations
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December 2015 in “Journal of Dermatological Case Reports” This case report highlights that intradermal testing may be more effective than patch testing for diagnosing delayed hypersensitivity reactions to intralesional corticosteroids like triamcinolone acetonide.
January 2022 in “Journal of Cutaneous and Aesthetic Surgery” Using truncal anesthesia on the supraorbital nerve reduces pain in hair loss treatments and improves patient comfort.
123 citations
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November 2003 in “Neuroscience Letters” In this study, TRPV4 channels were found in specific mechanosensory endings in mice skin, suggesting a role in pressure sensation transmitted through A- and C-fibers.
1 citations
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August 2021 in “Journal of The American Academy of Dermatology” This study investigates the effects of ice cooling and vibration on reducing pain during platelet-rich plasma injections for alopecia, especially due to concerns about lidocaine reducing PRP efficacy.
4 citations
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March 2019 in “Journal of Pure and Applied Microbiology” This study investigated the anti-inflammatory effects of a 940nm diode laser in Wistar rats with carrageenan-induced arthritis and found that a 74J/cm² energy density significantly reduced edema and restored function, whereas 171J/cm² neared thermal exposure limits for the skin.
13 citations
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December 2009 in “Journal of the Peripheral Nervous System” This laboratory study concluded that TRPA1 and TRPV1 channels do not play a role in mechanotransduction processes in slowly adapting type II mechanoreceptors in isolated rat sinus hair follicles.
6 citations
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September 2010 in “Archives of Dermatology” This case study suggests that thermography could objectively assess pain severity in herpes zoster patients by correlating thermal images with reported pain intensity.
September 2024 in “Journal of the American Academy of Dermatology” This article reviews the use of platelet rich plasma in treating androgenetic alopecia and discusses the potential limitation of pain from injections, without presenting new clinical results.
15 citations
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July 2002 in “Australasian Journal of Dermatology” In this case report, two plywood mill workers developed allergic contact dermatitis due to exposure to uncured phenol-formaldehyde resin, not sawdust as initially suspected.
19 citations
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October 2013 in “Headache: The Journal of Head and Face Pain” This review discusses conventional and alternative treatments for trigeminal autonomic cephalalgias, including cluster headache, paroxysmal hemicrania, and SUNCT, and recommends specific medications without reporting new clinical findings.
January 2009 in “Journal of musculoskeletal pain” This case report describes a patient who developed herpes zoster on the right knee following an intraarticular sodium hyaluronate injection, suggesting a possible link between the injection and the infection.
1 citations
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February 2021 This study observed that using ice pack compression or a vibration anesthesia device reduced pain during inactivated PRP scalp injections in patients with alopecia, suggesting both as inexpensive and accessible pain-relief options.
21 citations
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April 1990 in “Journal of comparative neurology” This study found that the spinal projection of afferents innervating slowly adapting mechanoreceptors had a greater rostrocaudal extent and number of boutons compared to those innervating rapidly adapting mechanoreceptors.
6 citations
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September 2021 in “Experimental Brain Research” In this study, researchers found that the glabrous skin of the rat forelimb contains sparse Meissner corpuscles and Merkel complexes, with more slowly adapting afferents in the palm and rapidly adapting afferents in the digit extremity.
189 citations
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May 1999 in “Microscopy Research and Technique” This review discusses the multifaceted roles of neurotrophins, especially nerve growth factor (NGF), in the development and function of nociceptors and reports no new clinical results.
12 citations
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June 2019 in “Psychoneuroendocrinology” This study found that in rodent models, the ability of D1 dopamine receptor activation to impair sensory gating is facilitated by 5α-reductase type 1, which produces allopregnanolone.
This study found that subcutaneous administration of Botulinum toxin type A significantly reduced histamine-induced itch intensity and neurogenic inflammation in human skin compared to saline.
66 citations
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July 2007 in “Journal of Molecular Medicine” This study in mice demonstrated that stress or nerve growth factor injection increases sensory neuron activity related to skin innervation, suggesting a strong connection between stress perception and neurogenic skin inflammation.
October 2021 in “JAAD Case Reports” This article discusses diabetic gustatory hyperhidrosis as a rare form of autonomic dysfunction linked to severe diabetic neuropathy and nephropathy, noting its impact on social and emotional well-being.