Delayed Hypersensitivity Reaction to Intralesional Triamcinolone Acetonide Following Treatment for Alopecia Areata: Intradermal Testing

    December 2015 in “ Journal of Dermatological Case Reports ”
    Firas Constantin Kreeshan, P. Hampton
    From the encyclopedia
    Triamcinolone Acetonide →
    Alopecia Areata →

    autoimmune disorder causing patchy hair loss

    Studysummary This case report highlights that intradermal testing may be more effective than patch testing for diagnosing delayed hypersensitivity reactions to intralesional corticosteroids like triamcinolone acetonide. Our plain-language summary of this paper — not a Tressless recommendation.
    The document described a case of a 35-year-old woman who developed a delayed hypersensitivity reaction to intralesional triamcinolone acetonide after treatment for alopecia areata. Patch testing was negative for triamcinolone but positive for budesonide, indicating a corticosteroid allergy. Intradermal testing with triamcinolone elicited a strong positive reaction, confirming the allergy. The study concluded that while patch testing is generally effective for detecting corticosteroid allergies, it may fail in some cases, and intradermal testing, though less safe, can be a more sensitive diagnostic tool.
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