96 citations
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March 2003 in “Life Sciences” This study found that acetylcholine levels in the superficial skin of atopic dermatitis patients were significantly higher compared to healthy volunteers, suggesting a potential role in skin cell regulation.
April 2024 in “Skin health and disease” In this case study, a patient developed parieto-temporal pain, tissue necrosis, and alopecia after receiving a hyaluronic acid injection for temporal augmentation, which was effectively treated with hyaluronidase and aspirin.
1 citations
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October 2005 in “Experimental and Clinical Endocrinology & Diabetes” This study found that in pregnant rats, the suppression of ACTH responses to IL-1β is linked to the action of endogenous opioids and AP, with AP potentially inducing opioid inhibition through increased pENK-A expression.
March 2012 in “Journal of The American Academy of Dermatology” Higher levels of certain nerve-related proteins are linked to hair loss in women with scalp pain.
39 citations
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October 2012 in “Headache The Journal of Head and Face Pain” This study reports cutaneous atrophy and alopecia in four patients following greater occipital nerve blockade with triamcinolone and lidocaine, suggesting that alternative steroids may reduce these side effects.
1 citations
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March 2024 in “Skin health and disease” This study found that vibration assisted analgesia reduced pain during intralesional corticosteroid therapy for hair loss, enabling treatment in a broader range of patients, including those with needle phobia.
74 citations
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January 2011 in “Reproductive Biology and Endocrinology” This study suggests testosterone gel administered for one year to male chronic pain patients receiving morphine may improve sexual function and mental health, despite limited effects on overall pain scores.
12 citations
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June 2010 in “Journal of dermatology” This study found that hyperpigmentation following contact immunotherapy for severe alopecia areata may indicate poor treatment responsiveness and aligns with characteristics of pigmented contact dermatitis.
May 2024 in “International journal of medicine and psychology.” This study found that ibuprofen was more effective than acetaminophen in reducing postoperative pain and inflammation after lower molar extraction, with patients experiencing lower pain scores and better reductions in inflammatory markers CRP and IL-6.
September 2025 in “PubMed” In this study, auricular electrostimulation effectively relieved dextran-induced pruritus in mice, comparable to loratadine treatment, and is attributed to down-regulating the H1R/TRPV1 signaling pathway and reducing inflammatory cells in the skin.
6 citations
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April 2012 in “Lasers in surgery and medicine” This study observed that persistent urticaria is a rare side effect of laser epilation, potentially linked to a hypersensitivity reaction in patients with allergies.
3 citations
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August 2017 in “Oral and Maxillofacial Surgery Cases” This study observed complete resolution of neuropathic pain symptoms in a patient after a fat grafting PRP procedure, suggesting it may be a less invasive treatment alternative.
5 citations
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September 1989 in “Journal of The American Academy of Dermatology” This article reports that cocaine injections can lead to skin lesions containing talc crystals at the sites of injection.
47 citations
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May 1994 in “Experimental Brain Research” This study observed that innervation of the mystacial pad in rats by fine-caliber axons is more extensive and complex than previously described, with distinct differences in labeling patterns depending on the tracer and survival time.
2 citations
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April 2022 in “PLoS ONE” This study reports that short exposure to vibration causes epithelial cells to retract filopodia, concentrate actin at their edges, and increase expression of the protease calpain, suggesting a mechanism for vibration-induced pain relief.
28 citations
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September 2008 in “Current Pharmaceutical Design” This review discusses hypersensitivity reactions to anticoagulants like ASA and heparins, highlighting their rare but potentially life-threatening nature, and emphasizes the need for meticulous allergy testing to find safe alternatives.
1 citations
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September 2017 in “Dermatologic Surgery” The cephalic approach for nerve blocks is less painful than the anterior approach during hair restoration surgery.
July 2025 in “Journal of Investigative Dermatology” Reduced AhR signaling in HS tunnels leads to persistent inflammation and microbial imbalance.
6 citations
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February 2019 in “Scientific reports” This study demonstrated that allopregnanolone administration caused significant scratching in atopic dermatitis mice, and ethanol-induced scratching may be linked to increased brain allopregnanolone levels.
October 2017 in “Anesthesia and Pain Medicine” This report observed that repeated stellate ganglion blocks over six years were associated with improved skin elasticity, increased water content, and more hair follicles on the treated side of a patient's face.
3 citations
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May 2015 in “Journal of The American Academy of Dermatology” Adalimumab significantly improves quality of life for patients with moderate to severe hidradenitis suppurativa.
19 citations
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March 2013 in “Headache The Journal of Head and Face Pain” This case report describes a 33-year-old woman whose unilateral occipital pain and localized alopecia were only responsive to onabotulinumtoxin A, suggesting it might be a form of cephalalgia alopecia or nummular headache.
June 2026 in “British Journal of Dermatology” This study found that subjective scalp sensations like hurting and burning are common among alopecia patients, with burning in particular showing a significant association with psychological distress in patients with lichen planopilaris and androgenetic alopecia, suggesting a potential psychoneuroinflammatory pathway.
March 2005 in “Journal of The American Academy of Dermatology” This article highlights the lack of research on the prevalence and characteristics of pain and itch in early stages of mild to moderate varicose vein disease, without reporting new findings.
September 2024 in “Journal of Cosmetic Dermatology” Cold gel compresses are the best for pain relief during scalp microneedling.
18 citations
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February 2023 in “Journal of Clinical Medicine” This study reported that neuropathic pain is prevalent in 6.7% of hospitalized COVID-19 patients during the acute phase and 34.3% of long COVID patients, highlighting the need for additional research.
August 2020 in “Bioscience Biotechnology Research Communications” This study found that using topical anesthetic was more effective than a vibrating device in reducing discomfort from dental injections.
May 2026 in “European Cells and Materials” In this study, researchers developed a novel delivery system using hyaluronic acid gels to encapsulate Huperzine A for Alzheimer's treatment, achieving extended release over 20 days and significantly improving pathology and behavior in mice, including enhanced memory and reduced neuroinflammation.
5 citations
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July 2022 in “IBRO Neuroscience Reports” This study found that camphor and similar compounds depress neural activity in rat mechanoreceptors, suggesting that their effects may not be mediated through TRP channels.
28 citations
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September 2002 in “The Journal of Comparative Neurology” This study found that presynaptic inhibition of Aαβ cutaneous primary afferents in cats is mostly mediated by GABAergic interneurons that also contain glycine.