Effect of Auricular Point Electrostimulation on Pruritus Induced by Dextran in Mice

The study investigated the effects of auricular electrostimulation on pruritus in mice induced by dextran. Twenty-four Kunming mice were divided into four groups: control, model, medication, and auricular electrostimulation, with 6 mice each. The model group showed increased scratching behavior and elevated levels of histamine 1 receptor (H1R), transient receptor potential vanilloid subfamily 1 (TRPV1), serum immunoglobulin E (IgE), and histamine (HIS). Both the medication and auricular electrostimulation groups demonstrated reduced scratching behavior and decreased levels of these markers, with no significant differences between them. Histopathological analysis revealed reduced inflammatory cells in the treatment groups compared to the model group. The findings suggest that auricular electrostimulation effectively alleviates pruritus by down-regulating the H1R/TRPV1 signaling pathway.