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This study developed an animal model that recreates alopecia areata by injecting healthy human skin grafts in immunocompromised mice with peripheral blood mononuclear cells enriched for NKG2D+ and CD56+ cells.

In this study, researchers developed a new humanized mouse model for alopecia areata that highlights the role of specific immune cells and may aid in discovering new treatments for the disease.

Minoxidil and platelet-rich plasma can help turn thin hair into thicker hair in male pattern baldness.

This paper discusses two preclinical models for studying alopecia areata and finds that testing new therapeutic agents should involve both the C3H/HeJ mouse model and the humanized mouse model for comprehensive insights.

This study using a humanized mouse model of androgenetic alopecia suggests that platelet-rich plasma may promote hair regrowth and improve hair characteristics in vivo.

Reducing neutrophils or inhibiting NETs improves wound healing in sickle cell disease.

This study created a humanized mouse model of hereditary vitamin D-resistant rickets that lacks alopecia, indicating the mutant receptor's potential to explore the syndrome's characteristics beyond vitamin D binding.

This study established a model using nude mice to successfully graft human scalp skin, maintaining hair follicle growth and skin integrity for at least two months, which may aid preclinical research.

In this study, activated PRP injections appeared to promote hair growth in AGA-affected scalp skin transplanted onto mice, compared to non-activated PRP.

No results are provided in this article as it lacks an available abstract, making it unclear what effects apremilast and tofacitinib have in a humanized mouse model of alopecia areata.

Minoxidil rejuvenates hair follicles and reduces aging signs in male pattern baldness.

This article reviews current treatments for alopecia areata, discussing the potential role of JAK inhibitors and noting the need for further clinical trials, but it reports no new results.

This study suggests that vellus to terminal hair follicle reconversion can occur in male pattern androgenetic alopecia using an in vivo model with minoxidil and platelet-rich plasma treatment.

This study observes that TYK2 inhibition with BMS-986202 may extend hair follicle growth phases and decrease inflammatory cell markers in alopecia areata, suggesting potential for clinical application.

This study found that a TYK2 inhibitor, BMS-986202, may restore immune privilege in hair follicles and promote hair regrowth in a humanized alopecia areata mouse model by inhibiting IL-12-mediated signaling.

This study developed a humanized scalp model in mice which demonstrated that transplanted cultured human hair follicle dermal cells contributed to the restoration of damaged hair follicles.

This study reported that the anti-γc antibody hC2 restored hair follicle homeostasis and suppressed hair loss in an AA-like mouse model by inhibiting autoreactive T-cell activity, suggesting that hC2 may offer a safer and more effective treatment for alopecia areata compared to current Jak inhibitors.

Apremilast may help treat hair loss in alopecia areata.

γδT cells can protect hair follicles from alopecia areata and promote hair regrowth.

This study tested a hydrogel microneedle patch delivering T reg attractants in mice with alopecia, finding it boosted regulatory T cell numbers at the site, leading to hair regrowth without causing peripheral immunosuppression, suggesting a potential new approach for autoimmune skin disease treatment.

This study found that humanized mouse models expressing mutated or reduced levels of the vitamin D receptor were able to maintain normal mineral homeostasis and prevent typical symptoms of vitamin D resistance.

This study found that combining UVB irradiation with anti-CD154 antibody improves the survival of hair follicle allografts in a humanized mouse model, suggesting a synergistic effect for allogeneic hair transplantation.

In this study, iNKT10 cells were found to play a significant role in preventing and treating alopecia areata in a humanized mouse model, suggesting these cells could have potential in managing related autoimmune disorders.

This study reported that using UVB preirradiation and anti-CD154 antibody treatment in a humanized mouse model prolonged hair follicle allograft survival and reduced immune cell infiltration without needing generalized immunosuppression.

This review discusses recent advances in understanding the Eda pathway's role in developmental biology, and highlights ongoing trials and areas for further research, including Eda's potential involvement in cell processes and disease.

This review discusses the limitations of animal models, particularly mice, in accurately predicting human skin wound healing outcomes and emphasizes understanding species-specific differences in skin characteristics for better translation to clinical settings.

This review explores animal models of alopecia areata, particularly focusing on the insights they've provided into the disease's immune mechanisms and potential treatment approaches, without reporting new experimental data.

This study presents a new mouse model for investigating chronic graft-versus-host disease, highlighting the role of human thymic tissue in developing multiorgan fibrosis driven by human immune cells.

In this study, a mouse model of scarring alopecia demonstrated significantly reduced CD200R expression in affected skin, which may contribute to immune attacks on hair follicles.