122 citations,
April 2011 in “European Journal of Pharmaceutics and Biopharmaceutics” Particles around 100 nm can penetrate and stay in hair follicles without passing through healthy skin, making them safe for use in topical products and useful for targeted drug delivery.
82 citations,
January 2002 in “Journal of drug targeting” Drugs penetrate scalp skin better than abdominal skin, with scalp hair follicles aiding in higher drug delivery.
64 citations,
January 2010 in “The FASEB Journal” Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.
51 citations,
September 2012 in “Biomacromolecules” Disulfide bonds make keratin in hair stronger and tougher.
46 citations,
January 2020 in “Theranostics” Injecting a special gel with human protein particles can help hair grow.
36 citations,
April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.
30 citations,
November 2013 in “PLOS ONE” Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.
26 citations,
February 2022 in “Journal of pineal research” Melatonin affects skin and hair color and protects skin cells, with potential benefits for hair growth and skin health.
12 citations,
July 2017 in “Scientific reports” Researchers developed a way to study human body clocks using hair tissue, which works similarly in both healthy and dementia patients.
9 citations,
November 2019 in “Scientific reports” The AC 2 peptide from Trapa japonica fruit helps protect hair cells and may treat hair loss.
9 citations,
August 2014 in “European journal of ophthalmology” PGF2α receptors in human eyelids are found in specific parts of hair follicles, explaining eyelash changes with glaucoma treatment.
9 citations,
September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.
6 citations,
July 2015 in “Journal of Investigative Dermatology” Chicken feather gene mutation helps understand human hair disorders.
5 citations,
April 2023 in “BMC Microbiology” Shampoo with heat-killed Lacticaseibacillus paracasei GMNL-653 improves scalp health and hair growth by changing scalp bacteria.
4 citations,
July 2020 in “Biochemical and Biophysical Research Communications” A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.
2 citations,
May 2023 in “Marine Drugs” Marine-derived saccharides may help reduce aging effects on skin and hair by promoting cell growth and collagen production.
2 citations,
January 2023 in “Scientific Reports” HIF-1α is important for hair growth and could be a treatment target for hair loss.
1 citations,
December 2011 Marine-derived ingredients show potential for hair health but need more human trials to confirm effectiveness.
December 2022 in “Journal of applied biological chemistry” Betula platyphylla extract, particularly the H3-2 fraction, may help treat hair loss by promoting cell growth and inhibiting a hair loss-related enzyme.
June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” ILC1-like cells can cause alopecia areata by attacking hair follicles.
October 2018 in “InTech eBooks” The gene Foxn1 is important for hair growth, and understanding it may lead to new alopecia treatments.
September 2018 in “Central Asian journal of medical sciences (Print)” Urticadioica L extract may enhance human hair growth.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” 17β-estradiol may help hair growth by increasing cannabinoid receptor type 1.
January 2014 in “Elsevier eBooks” The study concluded that genetic mutations affect human hair diseases and identified key genes and pathways involved in hair growth and cycling.
March 1998 in “Journal of dermatological science” Protease Nexin-1 is found in human hair growth cells and is affected by male hormones.
130 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).
81 citations,
July 2011 in “Lasers in Medical Science” The Lexington LaserComb helped regrow hair in mice with a condition similar to human hair loss.
13 citations,
June 2007 in “Journal of Dermatological Science” Researchers created a cell line to study hair growth and found specific genes affected by dihydrotestosterone.
12 citations,
May 2015 in “Molecular Medicine Reports” Troxerutin helps protect skin cells from oxidative stress and may be good for treating hair loss.
8 citations,
March 2020 in “Frontiers in Cell and Developmental Biology” Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.