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The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Low SULT activity in hair follicles leads to better response to oral minoxidil for hair loss.

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.

The enzyme PST is found in developing human kidneys and helps with detoxification and development.

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

The gel made of minoxidil and hydroxypropyl-β-cyclodextrin improves hair growth and is good for long-term use.

Understanding drug interactions, side effects, and patient-specific factors is crucial for effective dermatological care.

Sulfotransferase SULT1A1 activity may predict minoxidil treatment success for hair loss.

TGF-β2 plays a key role in human hair growth and development.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Colchicine can inhibit hair growth by affecting cell activity and protein expression in hair follicles.

New nonsteroidal molecules can potentially increase dihydrotestosterone in neurons by blocking certain enzymes, without affecting prostate and seminal vesicle weight.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

The study concludes that regulating apoptosis could lead to new treatments for various skin and hair conditions.

Human hair follicles can make and process prostaglandins, which may affect hair growth.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Human hair follicles produce and respond to erythropoietin, helping protect against stress.

Cysteine helps maintain keratin production in skin cells even when iron is low.

Human placental extract may help hair growth by affecting certain cell signals and could be more effective with minoxidil.

Substance from human umbilical cord blood cells promotes hair growth.