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New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

Women with hair loss should be checked for PCOS, as it's often related and early diagnosis can help with treatment.

Long-term use of finasteride in women can cause hormonal changes, DNA damage, and menstrual issues.

The severity of symptoms in nonclassical congenital adrenal hyperplasia is not determined by CYP21A2 gene variations.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Finasteride can reduce fertility in some men, but stopping it increases sperm count.

The nafarelin test can reliably distinguish between gonadotropin deficiency and delayed puberty in teenage boys.

High androgen levels and genetic factors likely cause Becker's nevus and related symptoms.

PCOS symptoms change with age; younger women have higher androgen levels and less metabolic issues, while older women face more metabolic challenges despite milder PCOS symptoms.

Postmenopausal women with hyperandrogenism didn't have better metabolic health even after their testosterone levels became normal.

The review recommends hormone replacement therapy for women with premature ovarian insufficiency to manage symptoms and protect health, with specific approaches for different groups.

People with alopecia areata often have lower levels of vitamin D, zinc, and folate, but more research is needed to understand if supplements can help treat it.

Women with androgenic alopecia are more likely to have polycystic ovaries and higher androgen levels, which may indicate PCOS.

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

Finasteride and spironolactone both reduce hirsutism, but finasteride lowers androgen levels more.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

Obesity is a major risk factor for insulin resistance in Taiwanese women with PCOS, which is also an independent risk factor for metabolic syndrome.

Sex hormones likely don't affect atopic dermatitis in adolescents and adults.

Clomiphene citrate improves fertility in men taking finasteride for hair loss.

Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

The document concludes that PCOS has a strong genetic component, but more research is needed to fully understand the specific genes involved.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Finasteride effectively treats baldness but may cause sexual side effects.

The current methods for diagnosing polycystic ovary syndrome are too vague and may lead to misdiagnosis and problems in research.

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

Diagnosing PCOS in teenagers is hard because its symptoms often look like normal puberty, and there's a need for better diagnosis methods and agreement on criteria.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Androgens significantly affect female hair loss, and hormonal treatments may help.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.