Gonadotropin Releasing Hormone Agonist (Nafarelin) Test to Differentiate Gonadotropin Deficiency from Constitutionally Delayed Puberty in Teenage Boys: A Clinical Research Center Study

October 1995 in “ The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism ”

Kanika Ghai, José Cara, Robert L. Rosenfield

gonadotropin releasing hormone agonist nafarelin gonadotropin deficiency constitutionally delayed puberty LH response GnRH agonist GnRH agonist

TLDR The nafarelin test can reliably distinguish between gonadotropin deficiency and delayed puberty in teenage boys.

The study evaluated the effectiveness of the GnRH agonist nafarelin in differentiating between gonadotropin deficiency (GnD) and constitutionally delayed puberty (CDP) in 34 teenage boys. It found that an LH response 4 hours post-administration could distinguish CDP from GnD in 95% of cases, with an incremental LH response below 4.8 IU/L being the best indicator. The nafarelin test was as effective as the sleep test, offering a reliable diagnostic tool for clinicians.

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Gonadotropin Releasing Hormone Agonist (Nafarelin) Test to Differentiate Gonadotropin Deficiency from Constitutionally Delayed Puberty in Teenage Boys: A Clinical Research Center Study

research Gonadotropin Releasing Hormone Agonist (Nafarelin) Test to Differentiate Gonadotropin Deficiency from Constitutionally Delayed Puberty in Teenage Boys: A Clinical Research Center Study

24 citations, October 1995 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

The nafarelin test can reliably distinguish between gonadotropin deficiency and delayed puberty in teenage boys.