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The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Opioid painkillers can cause many side effects, including breathing problems and addiction, but are generally considered safe when used properly.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

Use minoxidil for hair loss treatment; assess results after 6 months.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

Skin changes can help diagnose and manage endocrine disorders like thyroid problems, diabetes, and adrenal gland conditions.

Procyanidin compounds from grape seeds were found to significantly increase mouse hair growth.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Prostate cancer prevention includes diet changes, supplements, and medications, with more answers expected soon.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Certain drugs that block specific enzymes can help treat prostate diseases.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.