667 citations
,
May 2008 in “Genes & Development” This review discusses the biochemical and biological functions of histone demethylases and their potential involvement in human diseases, including cancer, but reports no new findings.
358 citations
,
January 1968 in “Physiological Reviews” Histamine plays key roles in immune responses, stomach acid, and brain signals.
170 citations
,
December 2009 in “Histopathology” This review discusses the histopathological diagnosis of scarring and non-scarring alopecias, emphasizing the importance of adequate tissue sampling and clinical information; it reports no new empirical results.
142 citations
,
March 2019 in “Frontiers in Cellular Neuroscience” This review discusses the development and potential therapeutic applications of adenosine receptor agonists and positive allosteric modulators, noting that while many clinical trials have been unsuccessful, initial results for new compounds are promising.
122 citations
,
April 1995 in “Journal of Cutaneous Pathology” The document describes how to tell different types of non-scarring hair loss apart by looking at hair and scalp tissue under a microscope.
98 citations
,
August 2007 in “PLoS ONE” This study found that Myc activation in epidermal stem cells leads to chromatin modifications that promote stem cell exit and differentiation, which can be influenced by HDAC inhibitors like trichostatin A.
97 citations
,
May 2008 in “Journal of Cutaneous Pathology” This review highlights the challenges in identifying histological features of adverse reactions to soft tissue fillers and emphasizes the need for increased awareness due to product uncertainty and delayed reactions.
95 citations
,
January 2004 in “Archives of Dermatological Research” This study found that peripilar signs on the scalp are linked to perifollicular lymphocytic infiltrates in early androgenetic alopecia, detectable even in areas with high hair density.
90 citations
,
June 2006 in “The American Journal of Dermatopathology” This review outlines the classification, histopathologic presentation, and pathogenetic concepts of scarring and nonscarring alopecias, reporting no new clinical results and emphasizing the need for clinicopathologic correlation.
74 citations
,
July 2008 in “Dermatologic therapy” This review discusses histopathologic findings in diagnosing primary cicatricial alopecias and emphasizes the importance of correlating histology with clinical presentation for accurate diagnosis; it reports no new results.
74 citations
,
November 2000 in “Archives of Dermatology” In this study, application of salicylic acid solution on mouse skin showed histologic changes without causing wounds or inflammation, observed immediately and up to 48 hours after treatment.
73 citations
,
November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” This review examines histochemical and immunohistochemical markers to differentiate apocrine and eccrine sweat glands, highlighting their distinct markers, though it reports no new clinical findings.
59 citations
,
February 2019 in “BMC Genomics” In this study, transcriptome analysis suggested that lipid metabolism and apoptosis may be key factors influencing hair length differences between short-hair and long-hair rabbits.
57 citations
,
August 1997 in “Microscopy Research and Technique” This review discusses novel molecular techniques in skin appendage research and summarizes the distribution of key molecules, but it reports no new experimental results.
54 citations
,
January 2018 in “Scientific reports” This study used proteomics to identify various proteins in human hair, which may help develop novel biomarkers for hair health, disease, and aging.
53 citations
,
February 2017 in “Journal of The American Academy of Dermatology” In this study of 20 patients with erosive pustular dermatosis of the scalp, using trichoscopy improved diagnosis, and treatments with high-potency steroids or topical tacrolimus effectively reduced inflammatory signs, suggesting these as first-line treatments.
53 citations
,
September 2011 Other common signs, not just the well-known immune cells around hair bulbs, are important for diagnosing hair loss from alopecia areata.
43 citations
,
May 2011 in “Dermatologic Therapy” This article discusses the phases and histological features of alopecia areata and reports no new clinical findings; the authors emphasize recognizing these phases for accurate diagnosis.
42 citations
,
July 2015 in “Drug Development and Industrial Pharmacy” This study concluded that Flutamide-loaded solid lipid nanoparticles may enhance hair follicle drug delivery and promote hair growth in androgenic alopecia compared to a Flutamide hydroalcoholic solution.
39 citations
,
May 2019 in “Journal of the American Academy of Dermatology” This study found that nonscarring alopecia in patients with systemic lupus erythematosus may indicate higher disease activity, as evidenced by specific histological and immunofluorescence changes.
38 citations
,
October 1988 in “Clinics in Dermatology” Minoxidil can help grow hair and make hair follicles bigger, but it can also cause side effects.
37 citations
,
April 1977 in “Journal of Cutaneous Pathology” This study found that specific histologic features in skin biopsies can help support a diagnosis of traumatic alopecia (trichotillomania), but not all markers are distinct to the condition.
35 citations
,
April 2009 in “Journal of Neuroscience Research” In this study, HDAC inhibitors promoted the differentiation of rat C6 glioma cells through the production of 5α‐reduced neurosteroids, enhancing serotonin-stimulated BDNF gene expression.
34 citations
,
February 2012 in “Journal of Cutaneous Pathology” This research retrospectively evaluated 92 skin specimens to propose histopathological criteria for diagnosing alopecia areata incognito, distinguishing it from telogen effluvium and androgenetic alopecia.
34 citations
,
January 2005 in “Journal of the American Veterinary Medical Association” This study found that cyclosporine A treatment at 5 mg/kg/day may reduce inflammation and promote gland regeneration in dogs with sebaceous adenitis, though symptoms returned when treatment stopped.
32 citations
,
June 2013 in “Journal of Investigative Dermatology” This study found that reducing HDAC1 activity in the skin of mice led to defects in hair follicle structure and pigmentation, highlighting HDAC's role in skin and hair maintenance.
31 citations
,
April 2019 in “Journal of Cutaneous Pathology” This review discusses the changes in hair follicles with aging, particularly graying due to decreased melanocyte activity, and suggests potential for hair repigmentation under certain conditions, but reports no new results.
31 citations
,
April 2016 in “Nature communications” This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.
31 citations
,
August 2005 in “The American Journal of Dermatopathology” This study investigated the histopathology of ectodermal dysplasia/skin fragility syndrome, identifying specific skin and hair abnormalities associated with PKP1 gene mutations in two young female patients.
31 citations
,
August 2000 in “Journal of Investigative Dermatology” This study found that when human hair follicles were grafted onto mice, they progressed through dystrophic stages and returned to normal growth, with stem cells aiding in recovery.