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In this study, researchers found that sesamin, a component of sesamum, modulated the AR-MAPK-Wnt signaling pathway in DHT-stimulated HaCaT keratinocytes, demonstrating potential multi-target activity against molecular events in androgenetic alopecia.

In this study using mouse models, researchers found that elevated IL-17a in aged olfactory epithelium impairs olfactory function, while IL-17a inhibition promotes regeneration and mitigates age-related decline.

In this study, researchers analyzed the chemical constituents of male and female Gynostemma longipes plants and different parts like roots and leaves, identifying significant variations in metabolites which could aid in assessing and selecting quality medicinal materials.

In this study on mice, researchers observed that dermal white adipose tissue (dWAT) plays a key role in regulating skin inflammation and tissue repair; however, reduced expression of certain cytokines in obese mice may hinder these processes, indicating potential metabolic disruptions in dWAT during inflammation.

This study found that volatile compounds from Bacillus subtilis strain WM13-24 improved root development in Arabidopsis by influencing auxin signaling.

This genetic study identified a potential interval for the Marie Unna hypotrichosis gene but found no mutations in the nearby hr gene, suggesting its involvement remains unconfirmed.

This study found that Nubian ibex have developed genetic adaptations in response to their desert environment, including enhanced skin barrier, DNA repair, viral response, and metabolism of toxic compounds.

This Ph.D. project aims to evaluate the self-assembling potential of hair keratin extracts and study the cellular response to both crude and purified keratins, highlighting their potential applications from biomedical to water remediation.

In this study, researchers will conduct a randomized, double-blind, multi-center clinical trial to assess the effectiveness of YH0618 granule in preventing chemotherapy-induced hair loss among breast cancer patients, aiming to understand its mechanism related to kidney deficiency in Chinese Medicine. Results are not yet reported.

This review discusses hormones that affect acne and highlights a statistically significant link between a low-glycemic-load diet and reduced acne activity, but reports no new experimental findings.

In this study, researchers observed that dormant TRP-2+ melanoma cells in bone marrow can interact with CD8+ T cells in tumor-bearing ret transgenic mice, potentially influencing immune responses.

In this study, researchers developed a method using stencils to create controlled stiffness gradients in alginate hydrogels, revealing that stiffer regions within the gels promote deeper invasion by breast cancer cells, facilitating the study of mechanosensitive cellular behaviors.

This research presents a comprehensive workflow for producing EMA-compliant autologous keratinocyte-based therapies for wound healing and explores miRNA-mediated regulations in human keratinocytes and adipose-derived mesenchymal stem cells.

In this study, FOL-026, a peptide based on osteopontin, was shown to promote angiogenesis and stimulate vascular cell proliferation and migration through neuropilin-1, similar to VEGF, suggesting potential therapeutic applications in vascular repair and angiogenesis-related conditions.

This study concludes that anti-androgenic chemicals causing short anogenital distance in male fetuses also induce a feminized transcriptional profile in the perineum, implicating Wnt and estrogen signaling in the process.

This review discusses the complex etiology of polycystic ovary syndrome (PCOS), highlighting its association with insulin resistance and hyperandrogenism, but reports no clinical findings; the authors suggest further investigation of the pathophysiological mechanisms.

This study found that SZ95 sebocytes and HaCaT keratinocytes exhibit distinct enzyme expressions and activities, implicating their different roles in androgen metabolism and homeostasis in vitro.

The study found that prolactin expressed in human scalp hair follicles acts as an autocrine modulator, inhibiting hair growth and promoting hair follicle regression, which may contribute to hair loss in hyper-prolactinemia patients.

This study found that hair follicles in both mice and humans may serve as an important site for melatonin synthesis and signaling, potentially influencing hair cycle regulation by modulating keratinocyte apoptosis.

In this study, researchers found that p75 neurotrophin receptor signaling affects apoptosis during hair follicle regression in mice, and altering its activity might help manage disorders involving early catagen entry.

This study found that human hair follicles express erythropoietin and its receptor, suggesting these follicles may use erythropoietin signaling to modulate apoptosis under stress conditions like hypoxia and chemotherapy.

In this study, four children with recurrent atypical teratoid rhabdoid tumors experienced disease stabilization or regression after treatment with alisertib, suggesting its potential role in future trials for this condition.

This study identified 63 genetic loci associated with male-pattern baldness, uncovering genes and pathways that may help develop treatments and suggesting its connection to other human conditions.

This study suggests that the HDAC9 gene is a third susceptibility gene for male-pattern baldness, with significant associations found in both German and Australian samples.

This study found that four days of simulated night shift work in healthy adults reduced insulin sensitivity, suggesting a potential increased risk of type 2 diabetes.

This study found that the signaling peptide CLE40 and receptor proteins CLV2 and CRN regulate root meristem differentiation through two distinct, antagonistic pathways activated by CLE40 in a dose-dependent manner.

This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.

The tropical legume Sesbania rostrata can form nodules in waterlogged conditions using a different method that involves plant hormones and specific genes.

In this animal study, atorvastatin co-administered with trastuzumab reversed trastuzumab-induced cognitive impairment (chemo-brain) and improved its anti-cancer efficacy without causing hair loss.

This study demonstrated that troxerutin may protect human dermal papilla cells from H2O2-induced damage and suggests potential in treating alopecia by inhibiting ROS-mediated cellular damage.