November 2024 in “Dermatology and Therapy” In this review, cosmetic practices such as non-ablative lasers, autologous fat injections, and oral isotretinoin may help alleviate certain symptoms of frontal fibrosing alopecia, while treatments like deep chemical peels and ablative laser therapies are contraindicated due to potential scarring risks.
5 citations
,
April 2021 in “Journal of Academic Research in Medicine” In this study, the free androgen index (FAI) was found to be a reliable marker for diagnosing and monitoring adolescent girls with hyperandrogenism, suggesting clinical reference values for PCOS, obesity, and idiopathic hirsutism.
17 citations
,
April 1997 in “Archives of dermatology” This case report describes the treatment of hirsutism in a 15-year-old obese Mexican girl with flutamide, aiming to improve her social function.
March 2025 in “Pakistan journal of physiology.” This hospital-based cross-sectional study found that a substantial proportion of women with female pattern hair loss also had metabolic syndrome, with no significant differences in frequency across age, disease duration, or hair loss pattern subgroups.
1 citations
,
February 2024 in “Journal of the European Academy of Dermatology and Venereology” Certain genetic factors may contribute to frontal fibrosing alopecia in Brazil.
4 citations
,
March 2022 in “BioEssays” This paper reviews how studying the microbiome of the freshwater polyp Hydra can inform new, microbiome-targeting therapies for human hair follicle and skin diseases; it presents no new experimental findings.
5 citations
,
May 2001 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE” This study developed a double-wavelength laser scanning microphotometer to measure hair shaft and follicle absorbance, improving spatial resolution and reducing light scattering effects in vitro.
166 citations
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April 2012 in “Journal of The American Academy of Dermatology” This study reviewed clinical data from 60 patients with frontal fibrosing alopecia and found increasing prevalence and generally poor response to treatment, with the cause remaining unclear.
This article reports no new findings as it lacks an abstract.
11 citations
,
May 2023 in “Journal of Cutaneous Medicine and Surgery” This study found that combining plasma rich in growth factors with conventional treatment significantly improved hair regrowth and reduced symptoms in patients with frontal fibrosing alopecia compared to conventional treatment alone.
19 citations
,
April 2013 in “Drug Development and Industrial Pharmacy” This study highlights the significance of the hf pathway for the skin permeation of ionized and hydrophilic high molecular compounds, and the usefulness of hf-plugging in evaluating their skin permeability.
1 citations
,
April 2021 in “Journal of The American Academy of Dermatology” Some overweight or obese men with long-term frontal fibrosing alopecia may have abnormal sex hormone levels.
October 2022 in “Regenerative Biomaterials” This study demonstrated that fibrin hydrogels support skin-derived precursors in hair follicle neogenesis in mice, with new hair growth and regeneration of blood vessels and sebaceous glands observed.
1 citations
,
July 2006 in “Reviews in gynaecological and perinatal practice” This review explores various therapeutic options for managing female hirsutism, emphasizing the effectiveness of low-dose finasteride and cyproterone acetate, but it presents no new clinical results.
April 2025 in “International Journal of Dermatology” This article proposes renaming frontal fibrosing alopecia to frontal fibrosing alopecia syndrome to better reflect its varied presentations and enhance understanding and treatment approaches.
195 citations
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May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology” This review discusses the diagnosis and treatment of hirsutism, emphasizing that a systematic evaluation can determine its cause, while combination therapy effectively manages the condition for most patients.
115 citations
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March 2019 in “Nature Communications” This study identified significant genetic associations with frontal fibrosing alopecia at four genomic loci, suggesting it is a genetically predisposed immuno-inflammatory disorder influenced by the HLA-B*07: 02 allele.
8 citations
,
July 2022 in “BMC neuroscience” In this study, intranasal delivery of hair follicle-derived stem cells improved neurological function and reduced brain damage in a rat model of ischemic stroke.
4 citations
,
April 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” This review highlights available treatments for frontal fibrosing alopecia, noting that 5-alpha reductase inhibitors, intralesional steroids, and hydroxychloroquine currently have the most evidence supporting their use, while other treatments show variable results and require further study.
2 citations
,
March 2018 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that both bFGF and herbal extracts significantly induced proliferation in human hair follicle mesenchymal stem cells, suggesting their potential for promoting hair growth.
5 citations
,
January 2023 in “International Journal of Molecular Sciences” This review discusses the expression of circadian genes in hair follicles and their potential for monitoring circadian-rhythm-related conditions, reporting no clinical results; the authors suggest combining hair sampling with other assessments for better insight.
159 citations
,
August 2010 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, hydroxychloroquine significantly reduced signs and symptoms of frontal fibrosing alopecia after 6 months of treatment, with maximal benefits observed within the first 6 months.
April 2023 in “World Journal Of Advanced Research and Reviews” This study in Morocco found that all women with frontal fibrosing alopecia presented frontotemporal hairline recession, with trichoscopic features such as perifollicular erythema and follicular hyperkeratosis being indicative of the condition, and suggested a potential link between cosmetic products or emotional factors and the disease.
This article discusses solitary hirsutism, emphasizing that treatment is mostly cosmetic unless contraception is also desired, and reports no new clinical results.
May 2015 in “Journal of the American Academy of Dermatology” Certain drugs and supplements may contribute to hair loss in the frontal hairline in older women.
3 citations
,
November 2020 in “Clinical, Cosmetic and Investigational Dermatology” This review summarizes the current treatment modalities for frontal fibrosing alopecia and provides a practical guide for clinicians, but reports no new clinical results.
12 citations
,
January 2016 in “Journal of clinical biochemistry and nutrition” In this study, combining deferasirox with sorafenib significantly reduced liver fibrosis and preneoplastic lesions in rats while also lessening adverse effects compared to sorafenib alone.
June 2026 in “British Journal of Dermatology” This study presents cases suggesting that hair transplantation may trigger de novo frontal fibrosing alopecia in some patients, highlighting a potential association worth considering as cosmetic hair procedures become more common.
June 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” The researchers reported that basement membrane heterogeneity, especially laminin α5 composition, plays a critical role in distinct inter-tissue interactions and hair cycle regulation in mouse hair follicles.
19 citations
,
March 2008 in “Nature clinical practice endocrinology & metabolism” A combined drug and laser treatment improved hirsutism in a PCOS patient, also enhancing her heart health and requiring regular liver and kidney checks.