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This study found that activating both PKM2 and Wnt/β-catenin signaling enhanced hair re-growth and HFSCs proliferation in mice, suggesting a potential treatment strategy for alopecia.

In this study, researchers found that dermal papilla cell exosomes can enhance hair follicle stem cell proliferation and reduce apoptosis through the Wnt3a/β-catenin signaling pathway, offering insights for potential hair problem treatments.

This review examines the potential of stem cells and their derived products, such as exosomes and conditioned media, in improving burn wound healing but presents no new clinical data.

This study found that treating aged mice with the Cdc42 inhibitor CASIN restored hair follicle stem cell functionality and improved hair regeneration by inducing anagen onset and increasing anagen skin areas.

In this study, transplantation of rat hair follicle stem cells was associated with reduced infarct volume and enhanced neurological recovery after ischaemic stroke, suggesting therapeutic potential for further clinical development.

This study found that hair follicle stem cells, when transplanted in a rat model of ischaemic stroke, migrated to affected areas, expressed neuron-specific markers, and reduced infarct volume, suggesting potential therapeutic benefits.

In this study, hair follicle stem cells were reported to accelerate burn wound healing and increase tissue tensile strength in rats.

This study found that the PPARγ modulator NAC-GED-0507-Levo may protect hair follicles from chemotherapy-induced damage, potentially offering a strategy to address irreversible hair loss in cancer patients.

This study reports that in mice, retinoic acid mediates communication between hair follicle and melanocyte stem cells by influencing differentiation in their shared niche during hair regeneration.

This study found that the PPAR-γ modulator AGED can reverse epithelial-mesenchymal transition in hair follicles affected by lichen planopilaris ex vivo, suggesting potential for treating scarring alopecias.

This study identified a specific subset of macrophages as a key source of oncostatin M, maintaining hair follicle stem cell quiescence during the resting phase in mice, suggesting a potential target for treating hair disorders.

In this study using a transgenic mouse model, Id2 overexpression in hair follicle stem cells prolonged quiescence by affecting gene expression, partly independent from BMP signaling.

This study found that N-acetyl-GED may protect and partially rescue human hair follicles from experimentally-induced epithelial-mesenchymal transition ex vivo, suggesting its potential in treating scarring alopecias like lichen planopilaris.

This study found that conditioned media from SHED stem cells cultured in STK2 media significantly stimulated hair growth in mice more effectively than media from HFSCs.

Hox genes control hair follicle stem cell regeneration in different body regions.

In this study, researchers demonstrated that the Id2 gene acts as a direct target and effector of BMP signaling, playing a key role in maintaining quiescence in hair follicle stem cells in vivo.

This study found that knocking out STAT5 expression in specific mouse hair follicles after tamoxifen treatment initiated uniform hair growth, highlighting STAT5's role in regulating the hair growth cycle.

This study found that hair follicle stem cells can proliferate and differentiate into keratinocytes on chitosan skin-engineered templates, suggesting potential applications in regenerative medicine.

This study found that topically applied nano-Zinc oxide accumulated in hair follicles and induced apoptosis in hair follicle stem cells, indicating a potential risk to skin homeostasis.

This review discusses the roles and characteristics of skin stem cells, their niches, and signaling pathways in skin maintenance, aging, and cancer, highlighting their potential in therapeutic applications but presenting no new clinical findings.

This study found that dihydrotestosterone alters the balance of Wnt pathway regulators in dermal papilla cells, hindering hair follicle stem cell differentiation and contributing to hair follicle miniaturization.

This study found that a modified scaffold with VEGF165 genetically modified hair follicle stem cells significantly promoted blood vessel growth and wound healing in rats, suggesting its potential as a skin substitute in clinical settings.

This study found that Wnt ligands secreted by the hair follicle epithelium are crucial for hair follicle regeneration in adults and could inform treatments for hair disorders like alopecia.

This study found that hair follicle stem cells show good biocompatibility with a heterogeneous bladder acellular matrix in vitro and in vivo, supporting potential use in bladder repair.

This study found that mouse hair follicle stem cells use symmetric cell division for maintenance and fate determination, and identified Gata6 as a crucial factor for their differentiation.

This study found that ROR2 plays a crucial role in the regulation of hair follicle stem cell self-renewal and maintenance, particularly by compensating for the absence of β-catenin.

This review highlights the importance of using 3D scaffolds in vitro to support hair follicle regeneration, emphasizing how these structures help maintain cell function and mimic the natural environment, which is crucial for developing hair follicle organoids for transplantation.

This review summarizes biological links between aging and androgenetic alopecia, particularly focusing on cellular senescence, and discusses potential therapeutic strategies, but reports no new clinical results.

This review discusses various tissue engineering approaches for hair follicle regeneration and biomaterials used, emphasizing its potential despite current clinical challenges.

This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.