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PCOS treatment focuses on lifestyle changes and specific medications to manage symptoms and complications.

Lower PPARγ levels and specific gene variations are linked to more severe Frontal Fibrosing Alopecia.

Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.

Understanding drug interactions, side effects, and patient-specific factors is crucial for effective dermatological care.

High-fructose diets can cause irreversible kidney damage.

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Liposomes could improve how skin care products work but are costly and not very stable.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.

Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.

Nanocarrier-loaded gels improve drug delivery for cancer, skin conditions, and hair loss.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.

Fat cells are important for tissue repair and stem cell support in various body parts.

Metformin and rosiglitazone both improved insulin use and hormonal symptoms in women with PCOS.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

New drug delivery methods can make natural compounds more effective and stable.

Using steroids can increase the risk of heart problems.

Teriflunomide is an effective and generally safe oral treatment for relapsing MS, reducing relapses and slowing disability progression.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.

Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

The new formulation improved the skin absorption of the drug Thiocolchicoside.