TLDR Old drugs can be used for new treatments, saving time and money, but there are challenges like needing more evidence and legal concerns.
The 2011 document highlights the concept of medication repurposing, which seeks new therapeutic applications for existing drugs, offering a cost-effective and time-saving alternative to developing new medications. It outlines the benefits of repurposing, such as the use of known safety profiles and faster access to treatments, but also acknowledges challenges like the lack of clinical evidence for new uses and potential legal issues. The document cites successful examples of repurposed drugs, including sildenafil and finasteride, and underscores the prevalence of off-label medication use, particularly in certain fields like pediatrics. Pharmacy practitioners are advised to stay informed about repurposed drugs and to critically evaluate the evidence supporting their new uses, while also considering safety and reimbursement issues.
38 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Finasteride effectively improves hair growth and slows hair loss in men with male pattern baldness.
114 citations
,
December 1951 in “Archives of Dermatology” Aminopterin strongly suppresses epithelial tissues and can treat certain skin conditions but has significant side effects.
11 citations
,
February 2004 in “Clinical and Experimental Ophthalmology” Taking Propecia might lead to the development of cataracts.
June 2024 in “Georgetown medical review” Finasteride treats hair loss but may cause low libido, erectile issues, and depression.
June 2017 in “Reactions Weekly” Finasteride (Propecia) may cause depression and suicidal thoughts; stop use and inform a healthcare professional if symptoms develop.
3 citations
,
June 2004 in “Annales De Dermatologie Et De Venereologie” Four new cases of gynecomastia (male breast enlargement) linked to finasteride (Propecia) have been found.
Finasteride is popular for treating male hair loss but may increase the risk of serious prostate cancer and has other potential side effects.
2 citations
,
January 2003 in “Journal of Clinical Dermatology” 1 mg finasteride can cause reversible painful breast enlargement in men.
