June 2024 in “British Journal of Dermatology” In this case report, an 80-year-old woman experienced darkening of previously grey hair, which may be linked to vitamin B supplementation, though its effectiveness is typically associated with reversing greying only in the presence of an initial vitamin B deficiency.
April 2026 in “Global Journal of Health Science” This study observed that patients with hypothyroidism-associated hair loss commonly have deficiencies in several vitamins and minerals, suggesting that these deficiencies may be linked to their condition.
November 2023 in “Cureus” In this study conducted in Jazan, Saudi Arabia, most participants were aware of vitamin D, zinc, and ferritin deficiencies and their link to hair loss, but only about a third practiced daily sun exposure and vitamin supplement use, highlighting a need for improved health education.
January 2025 in “Egyptian Journal of Dermatology and Venerology” This study found that COVID-19 vaccination initially lowered vitamin D levels in serum and hair but increased serum levels after the second dose, except for the Pfizer group. Hair vitamin D showed a nonsignificant increase, and hair loss was most common with the AstraZeneca vaccine.
50 citations
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October 2011 in “Archives of Biochemistry and Biophysics” This study found that while calcium can substitute for the Vitamin D receptor in maintaining epidermal keratinocyte differentiation, it cannot compensate for hair follicle dysfunction caused by the absence of the receptor.
18 citations
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October 2014 in “Experimental Biology and Medicine” This study found that feeding mice high levels of dietary vitamin A increased WNT signaling, which activated hair follicle stem cells and may have accelerated alopecia areata progression.
July 2016 in “Journal of Dermatology and Cosmetic” This study found that 66% of patients with hair loss also have vitamin D deficiency, with a significantly higher prevalence among women than men.
127 citations
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January 2008 in “PloS one” This study observed that the vitamin D receptor is crucial for hair follicle formation and altering tumor development in the Wnt signaling pathway, suggesting therapeutic potential for vitamin D analogues in related tumors.
25 citations
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March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that while VDR is crucial for maintaining hair follicles in mice, their degeneration may be linked to impaired cell migration during hair growth phases rather than stem cell loss.
15 citations
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January 2016 in “International journal of trichology” This study found that female students experiencing diffuse hair fall had significantly lower Vitamin D3 levels compared to healthy controls.
14 citations
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September 2021 in “Journal of Cosmetic Dermatology” This review discusses vitamin D's role in hair follicle biology and its association with hair loss but reports no conclusive evidence for its effectiveness as a treatment, indicating the need for further studies.
3 citations
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February 2016 in “Dermatologic Therapy” Using minoxidil and tretinoin on the skin, along with oral vitamin D, improved hair thickness and density in two girls with woolly hair.
2 citations
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June 2018 in “Sudan journal of medical sciences” In this case study, a 45-year-old woman's hair loss improved after three months of weekly high-dose vitamin D supplementation, emphasizing the importance of assessing vitamin D levels in patients with hair loss.
July 2025 in “Food Science & Nutrition” This study found that vitamin D supplementation in diets of Rex rabbits improved hair follicle development and fatty acid metabolism, with 1400–2100 IU/kg proving most effective for hair density and 2800 IU/kg increasing hair length.
June 2024 in “Sohag Medical Journal” This review reports that vitamin D plays an important role in hair follicle development, with a negative correlation observed between serum vitamin D levels and female pattern hair loss, suggesting further research is needed before recommending vitamin D as a treatment.
May 2023 in “International journal of molecular sciences” This study investigated the role of the ABCA4 gene in human keratinocytes and hair follicle stem cells and found that silencing the ABCA4 gene increases the harmful effects of all-trans-retinal on hair follicle stem cells.
April 2017 in “The FASEB Journal” This study suggests that excess dietary vitamin A may arrest hair follicles in refractory telogen in mice, while adequate levels promote competent telogen, revealing dose-dependent effects on hair cycling.
January 2017 in “International Journal of Trichology” This study observed that serum Vitamin D3 levels were low among South Indian students with diffuse hair fall, highlighting global hypovitaminosis D as a concern and suggesting possible dietary or sunlight exposure influences.
April 2008 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” The vitamin D receptor helps control hair growth and may protect against certain skin tumors.
October 2004 in “Radiotherapy and oncology” Active vitamin D3 might protect hair follicles from radiation damage.
3 citations
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June 2012 in “Korean Journal of Human Ecology” This study found that a supplement containing medicinal plant extracts, amino acids, and vitamins decreased hair loss and increased hair thickness over three months, without significant side effects, in participants with hair loss concerns.
1 citations
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September 2022 in “Journal of dermatological science” This study found that a combination of vitamins in hair care products promoted hair shaft elongation in a mouse model by activating the PlGF/VEGFR-1 signaling pathway.
September 2024 in “Journal of Family Medicine and Primary Care” This study found that primary health physicians in Saudi Arabia generally have low knowledge and practice scores regarding the use of vitamins and minerals for treating hair loss, with no significant difference between more or less experienced doctors.
January 1959 in “Acta medica Scandinavica” This article discusses the relationship between vitamins and scalp hair loss but does not report new clinical results.
11 citations
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March 2015 in “Life sciences” This study found that using conditioned medium from vitamin D3 pre-activated preadipocytes enhanced hair regeneration in mice by promoting angiogenesis.
3 citations
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January 2016 in “Journal of cosmetology & trichology” This report suggests that correcting nutritional deficiencies may improve hair quality in patients with Monilethrix and similar hair shaft disorders, though it is not a cure.
1 citations
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November 2011 in “Dermatologica Sinica” This study found a significant decline in serum zinc levels among women of African descent using hair relaxers and experiencing alopecia, with age at first exposure potentially influencing alopecia development.
1 citations
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August 2004 in “Alternative & complementary therapies” Non-drug methods like diet, supplements, and aromatherapy can help manage hair loss and its emotional impact.
May 2026 in “Archives of Dermatological Research” This study found that treating human hair with vitamin E and γ-oryzanol significantly reduced UV-B-induced structural damage, with γ-oryzanol providing greater protection, especially in female hair samples. The findings highlight these compounds' potential as cost-effective solutions for preserving hair integrity against UV damage.
May 2026 in “Preprints.org” This study found that a supplement containing cystine, B vitamins, and minerals improved hair condition in 34 women with diffuse hair loss over six months, as evidenced by an increased anagen/telogen hair ratio, positive participant feedback, and no serious side effects.