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AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

Mutations in certain receptors can cause diseases and offer new treatment options.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

Maize hybrids show better early growth due to complex gene interactions from their parent strains.

A new mutation in the DCAF17 gene was found in a Chinese family, causing Woodhouse-Sakati syndrome and diabetes.

Researchers created a model to understand heart aging, highlighting the role of microRNAs and identifying key genes and pathways involved.

A new mutation linked to partial Androgen Insensitivity Syndrome and prostate cancer was found in a patient unhappy with their female gender assignment.

The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Researchers created a model to understand heart aging, highlighting key genes and pathways, and suggesting miR-208a as a potential heart attack biomarker.

New treatments and management strategies for skin conditions like melanoma and Spitz naevi were discussed at the dermatologists' meeting.

JAGGED1 could help regenerate tissues for bone loss and heart damage if delivered correctly.

PlacMA hydrogels from human placenta are versatile and useful for cell culture and tissue engineering.

Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.

Minoxidil can reduce functions related to androgen receptors.

Immune cells in Hidradenitis suppurativa become more inflammatory and may be important for treatment targets.

Nanotechnology shows promise for better chronic wound healing but needs more research.

Small proline-rich proteins and trichohyalin help make epithelial tissues tougher and more flexible.

GALT5 and GALT2 are important for plant growth and development because they help with protein glycosylation.

The protein FLCN is involved in cellular cleanup and is regulated by ULK1.

Melanoma's complexity requires personalized treatments due to key genetic mutations and tumor-initiating cells.

The model shows that filament flexibility and amino acid differences affect how fast intermediate filament proteins assemble.

Understanding keratinization is crucial for treating skin conditions like ichthyoses and psoriasis.

JAK inhibitors show promise for treating various skin diseases.

Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.

Nitric Oxide has potential in medicine, especially for infections and heart treatments, but its short life and delivery challenges limit its use.

Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.

Mast cells and CD8 T cells interact closely in skin diseases, affecting each other's behavior and contributing to conditions like psoriasis and eczema.

Low Vitamin D receptor levels in breast cancer are linked to worse outcomes and more bone metastases, and could be a marker for prognosis.

PRP helps skin heal, possibly through special cells called telocytes.