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This study concluded that hair-derived stem cells from older donors may offer a promising alternative for autologous corneal endothelial replacement, potentially benefitting patients of various age groups.

This study found that overexpression of sFRP4 in skin cells reduces Wnt signaling activation, leading to decreased melanocyte differentiation in regenerating hair follicles.

In this mouse model study, researchers found that deleting the ASH2L gene in epidermal progenitor cells led to thinner epidermal layers, delayed hair follicle development, and reduced epidermal stem cell pools, with alterations in genes related to hair follicle development and the Notch signaling pathway.

This study found that CTCF is crucial for proper skin and hair follicle development in mice, affecting keratinocyte differentiation and gene expression in keratin loci.

This study found that JNK plays a dominant role in hair follicle matrix density-dependent proliferation and differentiation, suggesting that collagen bundling affects keratinocyte dynamics.

In this ex vivo study, inhibiting Ezh2 with a small molecule slowed human hair growth by decreasing proliferation and increasing apoptosis in the outer root sheath.

This study found that mesenchymal stem cells showed potential to differentiate into hair follicle stem cells when induced by the supernatant of cultured hair follicles in vitro.

This study found that androgens inhibit hair follicle stem cell differentiation by disrupting the Wnt signalling pathway in dermal papilla cells, but Wnt activation can restore differentiation.

This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.

This study found that androgens downregulate BMP2 in dermal papilla cells, inhibiting hair follicle stem cell differentiation, while BMP2 addition may restore hair lineage differentiation through the Wnt/β-catenin pathway.

This study observed that HAP stem cells from the whiskers of young mice near the ear differentiated into heart-muscle cells more efficiently than those from older mice or other whisker locations.

This study found that basal cell carcinoma cells differentiate along hair follicle lineages and may be influenced by hair follicle cycle modulators for potential therapeutic targeting.

This study found that m6A-circHECA enhances the differentiation of stem cells into hair follicle lineages in cashmere goats by sequestering miR-449a-5p, boosting LEF1 gene expression, and activating the Wnt/β-catenin pathway.

This study found that VEGFR-2 activation may play a role in hair follicle differentiation, proliferation, and apoptosis by co-expressing with several key proteins in normal human scalp skin.

This study found that DNA methylation regulates hair follicle differentiation in cashmere goats by suppressing gene expression during induction and enhancing it during differentiation, with potential involvement of specific lncRNAs.

This study found that hair follicle stem cells in mice have an unexpected ability to adaptively determine their differentiation pathways, maintaining tissue architecture despite external stimuli.

Asymmetric hair follicle differentiation causes the unique shape of kinky hair.

This study found that PlncRNA‑1 may enhance the proliferation and differentiation of hair follicle stem cells by upregulating the TGF‑β1-mediated Wnt/β-catenin signaling pathway.

This study found that BMP2 increased PTEN expression and induced autophagy, promoting hair follicle stem cell differentiation in both in vitro models and a mouse wound model.

This study found that circRNA-1926 promotes hair follicle stem cell differentiation in cashmere goats by sponging miR-148a/b-3p to increase CDK19 expression.

This study found that miR-203a-3p downregulates Smad1, promoting the differentiation of loureirin A-induced hair follicle stem cells, suggesting it could be a potential therapeutic target for skin wound healing.

This study found that nestin-negative hair follicle stem cells can differentiate into neural stem cell-like cells, but not mature neurons, through a multi-step neuro-induction process.

This study confirmed the biological characteristics and multipotent differentiation potential of primary and secondary hair follicle stem cells from Arbas Cashmere goats, contributing to the understanding of adult stem cell types and characteristics.

This study found that 0.5μg/ml silibinin significantly promoted the differentiation of hair follicle stem cells into neurons, while higher concentrations were toxic and lower ones had no effect.

In this study, silibinin at 0.5 μg/ml significantly promoted hair follicle stem cell differentiation into neurons in rats, while higher concentrations were toxic.

This study found that Notch signaling is crucial for maintaining proper melanocyte distribution and preventing premature differentiation in the melanocyte lineage within hair follicles.

This study found that thyroid hormones T3 and T4 enhance keratin 15 promoter activity and stimulate CD200 expression in epithelial stem cells from human scalp hair follicles, affecting their growth and differentiation.

This study identified trichohyalin as an early differentiation marker in hair follicles, with potential structural roles related to alpha-helical formations, based on the partial characterization of its cDNA in sheep.

This study observed that undifferentiated matrix cells at the base of the hair follicle differentiate into the medulla, cortex, cuticle, and inner root sheath cell types through specific morphological changes.