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Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

The document concludes that certain chemicals can help maintain stem cell pluripotency and that understanding cell states is crucial for tissue regeneration.

Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.

Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.

ΔNp63α stops TAp73β from working in skin cancer by blocking its access to specific genes, not by directly interacting with it.

The study found that women with hyperandrogenic PCOS have higher levels of AKT1 and AKT2 proteins in their cells, which may lead to cell dysfunction.

The research explains how a human enzyme binds and processes its substrate, which could relate to its role in biological functions and hair loss.

Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.

The study concludes that certain domains in Clostridium histolyticum enzymes are structurally unique, bind calcium to become more stable, and play distinct roles in breaking down collagen, with potential applications in medicine and drug delivery.

Dihydrotestosterone causes p27 protein breakdown in ovarian and breast cancer cells by binding with SKP2.

Microneedling with 5% minoxidil improves hair loss in Chinese men by activating Wnt/ß-catenin pathway.

Deleting Snai2 and Snai3 causes fatal autoimmunity.

A new mutation in the AGPAT2 gene causes severe fat tissue loss and related health issues by reducing the protein's levels.

Researchers created a model to understand heart aging, highlighting the role of microRNAs and identifying key genes and pathways involved.

Mouse hair follicle stem cells lose their ability to change into different cell types after being grown for a long time.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.

Two-photon microscopy helps observe hair follicle stem cell behaviors in mice.

Toxic epidermal necrolysis is a severe skin reaction often linked to drugs, requiring careful medication use and supportive care.

Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

Minoxidil prevents serotonin loss from MDMA by affecting potassium channels and increasing Akt phosphorylation.

Methionine restriction works better than betaine for treating CBS deficiency symptoms in mice.

Glycine reduces skin pigmentation by lowering melanin production.

The authors suggest systematically sourcing new product ideas from various internal and external places to improve innovation.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

The ketogenic diet can worsen biotin deficiency, suggesting a need for biotin supplements.

Orobanche rapum extract rejuvenates skin and protects skin bacteria, leading to healthier skin.

Epidermal stem cells have potential for personalized regenerative medicine but need careful handling to avoid cancer.

Post-finasteride syndrome's existence is uncertain; more research needed.