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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

Diet changes can protect against harmful environmental effects on fetal development.

Androgen deprivation therapy for prostate cancer can cause sexual, physical, and psychological side effects, and doctors should manage these carefully.

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Oestrogens are key for bone growth during puberty in both boys and girls.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Modern science supports the use of some Ayurvedic plants for health, as ancient practices suggested.

Masculine facial features may not reliably indicate heritable health, and more research is needed.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

Fat cells in the skin help start healing and form important repair cells after injury.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

No single treatment is consistently effective for alopecia areata, and more research is needed.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

Finasteride doesn't harm male fertility or sperm quality, but may slightly reduce ejaculate volume.

DHT may increase the risk of heart disease and death in elderly men.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Finasteride may cause slight depression and anxiety.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Lower SHBG levels may increase the risk of PCOS.