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This study found that women with androgenetic alopecia were more insulin resistant than healthy controls, suggesting the use of beta cell function and insulin sensitivity indices to measure insulin resistance in this population.

This systematic review found that cinnamon supplementation may modestly improve insulin sensitivity and potentially reduce hyperandrogenism in women with PCOS, but stresses the need for large-scale clinical trials.

This study found that lean women with PCOS have a similar degree of tissue insulin resistance as obese women with PCOS, suggesting that insulin resistance may be a primary feature of the syndrome.

This study found that men with early-onset male pattern alopecia did not significantly differ from healthy individuals in cardiovascular and metabolic measures, but hsCRP and galectin-3 were linked to cardiovascular risk factors in those with the condition.

In this study, ovarian SAHA was found to be independently associated with a more insulin-resistant profile and increased risk of glucose abnormalities in women with PCOS, beyond common risk factors.

This study suggests that dietary decanoic acid may manage hyperandrogenism and insulin resistance in PCOS, as observed in animal and cell model experiments.

This study discusses the potential of targeting 11β-HSD1 for treating metabolic syndrome and highlights emerging promising data from human trials on selective 11β-HSD1 inhibitors.

This review reports that treating polycystic ovary syndrome in adolescents with anti-androgens and weight loss is beneficial, and suggests that metformin may be useful for symptom management and prevention.

This study found that combining fructose and DHT in rats successfully mimicked the clinical phenotypes of non-lean PCOS, providing a novel rodent model for this condition.

This review discusses the potential of targeting glucocorticoid action as a treatment strategy for obesity and type-2 diabetes, highlighting promising animal study results but reports no new clinical findings.

This study found that mice lacking myelin protein zero-like 3 (Mpzl3) had reduced body weight and adiposity despite increased food intake, which was linked to higher energy expenditure and improved glycemic control.

In this research, animal tests confirmed that chromium supplementation effectively maintains glycaemic and insulinaemic balance and affects certain hormone levels, but the authors note that clinical evidence for chromium's benefits in PCOS treatment remains sparse and inconsistent, warranting further exploration.

This review highlights the role of disrupted glycolysis in exacerbating reproductive and metabolic abnormalities in PCOS and suggests that agents like metformin and resveratrol may help restore glycolytic balance and improve ovarian function.

This study suggests that selenium deprivation in mice accelerates age-related degeneration but paradoxically promotes longevity, potentially decoupling healthspan from lifespan.

This study suggests that metformin has a stronger impact on gonadotroph hormone levels in men with early-onset androgenic alopecia compared to those with normal hair growth.

This review indicates promising potential for cinnamon supplementation to improve metabolic outcomes in PCOS, but more clinical trials with higher doses and longer durations are needed to confirm these effects.

This study observed two distinct phenotypes among North Indian women with PCOS: obese hyperinsulinaemic dysglycemic women from Delhi and lean hyperandrogenic women from Srinagar, despite being in the same region.

This study found that subclinical hypothyroidism had minimal impact on the metabolic and hormonal profiles of women with polycystic ovary syndrome.

This study found that curcumin may improve glycemic control and certain aspects of lipid metabolism in patients with polycystic ovary syndrome.

This review discusses the complexities and challenges in treating polycystic ovarian syndrome and concludes that while lifestyle and insulin-sensitizing treatments show promise, randomized controlled trials are lacking.

This study found that metformin's metabolic benefits, such as reducing fat content and improving insulin sensitivity, were less pronounced in men with early-onset androgenic alopecia compared to those with normal hair growth, possibly due to differences in systemic inflammation and vitamin D status.

In this study, transgenic male mice over-expressing the androgen receptor in mesenchymal stem cells showed reduced fat mass and improved glucose clearance, suggesting enhanced androgen sensitivity may alter body composition.

In this study, a high inositol diet, with or without supplements, significantly improved androgen levels, insulin sensitivity, and certain metabolic indicators in women with PCOS over three months.

In this quasi-experimental study, a 12-week intermittent fasting regimen significantly improved insulin sensitivity and reduced HbA1c levels in overweight South Asian adults with prediabetes, suggesting a practical lifestyle strategy to potentially delay the onset of type 2 diabetes.

This study found that reduced plasma DIAPH1 levels were associated with polycystic ovary syndrome, suggesting DIAPH1 as a potential predictive factor for the condition.

This study found that four days of simulated night shift work in healthy adults reduced insulin sensitivity, suggesting a potential increased risk of type 2 diabetes.

This study suggests that young women with low prolactin levels may face higher cardiometabolic risk, and reducing cabergoline dosage reversed related metabolic disturbances.

Small hormonal imbalances can cause significant health problems, so more sensitive testing for hormone-disrupting chemicals is needed.

This study reviews current treatments for PCOS and evaluates Tirzepatide as a potential option for its management, suggesting possible benefits for those with obesity and metabolic syndrome but not for those of normal weight.

This study found that curcumin may improve glycemic control and lipid metabolism in patients with PCOS, although its effects on low-density lipoprotein and triglycerides were not significant.