Tissue Insulin Sensitivity and Body Weight in Polycystic Ovary Syndrome

    August 2001 in “ Clinical endocrinology ”
    Philippa J. Marsden, Alison Murdoch, Roy Taylor
    TLDR Lean and obese women with PCOS have similar levels of insulin resistance, indicating it's a core aspect of the condition.
    The study investigated tissue insulin sensitivity in lean and obese women with polycystic ovary syndrome (PCOS) compared to control subjects. It included 6 lean and 14 overweight PCOS patients, and 8 controls. Results showed that both lean and obese PCOS patients had elevated fasting insulin levels and low insulin receptor binding, with no significant difference between the two groups. Lean PCOS patients had higher plasma LH levels than obese ones, and there was a strong inverse correlation between BMI and LH levels. The findings suggested that insulin resistance might be a primary feature of PCOS, potentially due to genetic factors in lean subjects or secondary to obesity in overweight subjects.
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