Tissue Insulin Sensitivity and Body Weight in Polycystic Ovary Syndrome

    August 2001 in “ Clinical endocrinology ”
    Philippa J. Marsden, Alison Murdoch, Roy Taylor
    TLDR Lean and obese women with PCOS have similar levels of insulin resistance, indicating it's a core aspect of the condition.
    The study investigated tissue insulin sensitivity in lean and obese women with polycystic ovary syndrome (PCOS) compared to control subjects. It included 6 lean and 14 overweight PCOS patients, and 8 controls. Results showed that both lean and obese PCOS patients had elevated fasting insulin levels and low insulin receptor binding, with no significant difference between the two groups. Lean PCOS patients had higher plasma LH levels than obese ones, and there was a strong inverse correlation between BMI and LH levels. The findings suggested that insulin resistance might be a primary feature of PCOS, potentially due to genetic factors in lean subjects or secondary to obesity in overweight subjects.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 137 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

      in Female  42 upvotes 3 years ago
      User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.

      community Having androgen receptor density and sensitivity at wrong f*ing place

      in Satire  7 upvotes 1 month ago
      The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

      community Bloodwork after 8 months on finasteride, is this normal?

      in Update  28 upvotes 7 months ago
      A user on finasteride for 8 months shared bloodwork results showing increased testosterone and estradiol levels, with concerns about high LH. Responses advised monitoring for symptoms but noted levels are within reference ranges.

      community Finasteride and Metformin together?

      in Finasteride/Dutasteride  1 upvotes 1 year ago
      The conversation is about whether it's safe to take Metformin for weight loss and Finasteride together, with the concern that Finasteride is not commonly used for hair loss treatment in the user's location, and their doctor is not knowledgeable about it.

    Similar Research

    6 / 1000+ results