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Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Metformin and rosiglitazone both improved insulin use and hormonal symptoms in women with PCOS.

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

Mice without active or present vitamin D receptors maintain normal blood sugar control and islet gene expression when calcium levels are normal.

Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

FOXO1 is important for wound healing, but its dysfunction in diabetes can slow the healing process.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

Early treatment and weight management are important for teenagers with PCOS to reduce symptoms and long-term health risks.

Hormonal therapies are effective for managing hair and skin symptoms in women with PCOS.

Curcumin may improve blood sugar levels and cholesterol in people with PCOS, but more research is needed.

Ziziphus spina-christi leaf extract lowered blood sugar and protected organs in diabetic rats.

Women with PCOS often have metabolic issues like insulin resistance and a higher risk of diabetes and abnormal lipid levels.

Medications for glucose metabolism and weight control, combined therapy options, and herbal medicines may help regulate menstrual cycle in adolescents with PCOS.

Insulin resistance is linked to PCOS and can lead to other health issues, but treatments like metformin can help manage symptoms.

Severe insulin resistance can be managed with medication, lifestyle changes, and treatment for related conditions.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Some Middle Eastern plants may help treat diabetes and could be alternatives to current drugs, but more research is needed.

New treatments for PCOS focus on insulin resistance and reducing testosterone levels, along with traditional hormone therapies.

Treating hirsutism in women often requires a mix of medications and cosmetic methods for best results.

Diagnosing and treating PCOS in teenagers is difficult, and the focus is on lifestyle changes and medication to improve health and prevent future issues.

A diabetic cat with another gland issue got better after treatment with cabergoline, no longer needing insulin.

Oxidative stress worsens PCOS by damaging cells and disrupting metabolism, suggesting antioxidant treatments might help.