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Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Long-term fluticasone treatment does not harm the immune system in horses with heaves.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

We need better ways to test and understand SARMs to make safer and more effective treatments.

Thyroid hormones affect skin texture, hair and nail growth, and can cause skin diseases related to thyroid problems.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

Researchers found a gene in hamsters that responds to male hormones and may be indirectly controlled by them.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Adrenal disorders can cause lasting brain and behavior issues in children.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

A woman with Cushing's syndrome improved after surgery to remove a tumor causing the condition.

Shift work disrupts the body's natural clock, leading to health problems.

CRISPR/Cas9 has improved precision and control but still faces clinical challenges.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Two types of 5α-reductase are in dog skin, which might make dutasteride better than finasteride for treating dog hair loss.

PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.

Interferons are effective for some skin conditions and cancers, but can have side effects and need more research for optimal use.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

Targeting the Smoothened receptor shows promise for treating certain cancers.