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Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

Flutamide reduces hair growth better but has more side effects.

Diane 35 plus finasteride is more effective in reducing hair growth and androgen levels, but may decrease libido.

Hidradenitis suppurativa improves with antiandrogen therapy.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Men with early hair loss have similar hormone levels to women with PCOS, possibly increasing risk of obesity and heart issues.

High testosterone to epitestosterone ratio in hair could predict male-pattern baldness.

Androgens significantly affect female hair loss, and hormonal treatments may help.

Ketoconazole reduced hair growth and improved acne in women, but caused side effects needing careful monitoring.

Hormones might affect the skin condition hidradenitis suppurativa, but their exact role is unclear.

Obese women with PCOS are more likely to have fatty liver disease.

Combination drug therapy is effective for hirsutism that doesn't improve with just one medication.

Patients with acanthosis nigricans often have insulin resistance and signs of increased male hormones, but treatment targeting these male hormones is generally ineffective.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

Women with only irregular periods or excess hair have a better hormone profile than those with full PCOS, but both groups are similar, indicating a need for better PCOS diagnosis methods.

Eating paradise nuts led to selenium poisoning, causing nausea, hair loss, and other symptoms in two women.

The conclusion is that accurately identifying the cause of high androgen levels in women with PCOS is crucial and requires specific tests.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Men can report their own balding patterns well enough for large health studies.

Insulin-sensitizing drugs like metformin can help with ovulation, weight loss, and lower testosterone in some women with PCOS.

High androgen levels and genetic factors likely cause Becker's nevus and related symptoms.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Finasteride reduces hirsutism effectively with fewer side effects but is a second-choice treatment due to safety concerns.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

Suppressing certain hormones might help prevent prostate cancer.

Testosterone replacement may help post-menopausal women with androgen insufficiency, but more research is needed on its benefits and risks.

Spironolactone successfully treated hair loss in a 9-year-old girl.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

Age, smoking, and lower BMI increase facial wrinkles; men wrinkle more than women, except in old age; pale skin and certain hormonal factors can protect against wrinkles.