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Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

Keeping β-catenin levels high in mammary cells disrupts their development and branching.

WNT10B is linked to cancer development and affects survival and disease progression in various cancers.

Cathepsin L is essential for normal hair growth and development.

Sostdc1 controls the size and number of hair and mammary gland structures.

Msx2 deficiency in mice leads to bone growth and organ development problems.

The document explains breast development, common breast conditions, and their treatments.

Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.

Hormones and signaling pathways control sebaceous gland function and could help treat acne.

Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.

Supplemented Erzhi Wan may help regrow hair in male pattern baldness by affecting certain cell signaling pathways.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Fat cells are important for tissue repair and stem cell support in various body parts.

Bioengineered salivary glands in mice can produce saliva when tasting sour or bitter, but have different protein levels and nerve signals compared to natural glands.

Helminth protein helps wounds heal better by reducing scarring and promoting tissue growth.

Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

Androgens and other hormones affect hair growth and skin conditions like acne.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.

CYP2B12 enzyme in skin cells converts arachidonic acid into specific bioactive lipids.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

Blocking BMP signaling causes hair loss and disrupts hair growth cycles.

Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

Scientists made working salivary glands in mice using bioengineered cells, which could help treat dry mouth.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.

Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.