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The researchers found that SPF50+ sunscreens provided the highest DNA protection against solar-simulated radiation in a reconstituted human epidermis model, with formulation type not affecting efficacy for a given SPF.

This study reported that sunscreen with SPF50+ provides a high level of DNA protection against UV-induced damage in a reconstituted human epidermis model, comparable to that in skin explants.

This research suggests that the vitamin D receptor may regulate hair follicle cycling and provide genoprotection against skin carcinogenesis through a mechanism independent of 1,25-dihydroxyvitamin D3, based on evidence from mouse models.

This review discusses two approaches to address aging: a tactical method to delay and slow age-related issues, and a strategic method aiming to eliminate aging altogether by targeting its root cause.

This study suggests that geranyl acetate may offer protective, anti-inflammatory, and cytoprotective effects against PPD-induced toxicity in keratinocyte cells, indicating its potential as a plant-derived treatment.

This review suggests that skin may largely protect itself from CYP-generated reactive metabolites due to higher conjugating enzyme activities, while highlighting limitations in modeling human skin metabolism experimentally.

This review explores the diverse roles of rosemary, covering its nutritional and medicinal uses, cosmetic and pharmaceutical applications, and evaluates various extraction methods, with a focus on sustainable practices and commercial prospects.

This study demonstrates that keratinocyte cell lines derived from cultured hair follicles can fully differentiate in organotypic skin models, offering a minimally invasive alternative to obtaining keratinocytes for research.

This study assessed mice's hematology and serum enzymes under sodium arsenite toxicity and observed that Aegle marmelos fruit extract reduced liver and kidney damage, mitigating the toxin's effects by maintaining normal enzyme levels when both were administered together.

This study found that donor age and culture medium significantly impact the quality of human full-thickness skin models, with implications for their use as animal model alternatives in research.

In this study, oral spermidine supplementation was found to significantly prolong the hair follicle anagen phase and reduce hair loss, with effects persisting three months after treatment in healthy participants, suggesting potential therapeutic benefits for hair loss conditions.

This review discusses how circadian clocks may influence diverse physiological functions beyond their established role in daily timekeeping, but it reports no new experimental findings.

Spironolactone might help protect against severe lung problems in COVID-19 patients.

This study found that Origanum vulgare extract improved testicular structure and function in mice against finasteride-induced damage by enhancing antioxidant defense and modulating gene expression related to apoptosis.

This review explores the effectiveness of seed cycling, a modern alternative medicine approach, in treating polycystic ovary syndrome and reports no new clinical results.

In this study, researchers analyzed the waters of Ladakh's hotsprings, identifying 27 bioactive compounds with potential health benefits, but emphasize that further clinical trials are needed to confirm their therapeutic efficacy and safety.

COVID-19 can cause different types of hair loss, with telogen effluvium being the most common.

This conceptual paper proposes evaluating the Ayurvedic formulation Moorvadi choornam for alleviating side effects of chemotherapy, including symptoms consistent with Garavisha lakshanas, but reports no clinical outcomes.

This review examines the development and challenges of using PROTACs, a targeted protein degradation strategy, to treat cancer by degrading specific proteins like PARPs and GPX4, highlighting issues such as target diversification and bioavailability.

In this study, the safety profile of the prodrug CAP7.1 was found to be similar to other topoisomerase inhibitors, with myelosuppression as the main dose-limiting toxicity.

This source reports on advances in stimulus-responsive nanoparticle-based PROTACs (nano-PROTACs), which aim to overcome existing challenges like poor cell permeability and systemic off-target effects by enabling controlled protein degradation through endogenous or exogenous stimuli, potentially enhancing therapeutic efficacy and reducing toxicity.

This review highlights the potential of PROTACs to transform cancer treatment by selectively degrading oncogenic proteins, overcoming drug resistance, and reducing toxicity; it also discusses challenges in optimizing these therapies for personalized applications.

This study found that apocynin restored collagen production, reduced DNA damage and senescence, and protected skin stem cells from aging in UVB-exposed human keratinocytes.

Some treatments can improve skin's defense against damage, but overuse may cause other skin problems.

In this study, lysocellin induced G1 phase arrest in human osteosarcoma cells, but diminished the cytotoxic efficacy of etoposide, while its derivative alopestatin may reduce etoposide-induced alopecia in a rat model.

This article discusses the potential for combining PROTACs with other therapeutic modalities in drug discovery and reports no clinical results.

This study found that the PPARγ modulator NAC-GED-0507-Levo may protect hair follicles from chemotherapy-induced damage, potentially offering a strategy to address irreversible hair loss in cancer patients.

This review highlights the potential of PROTAC technology in drug discovery for previously undruggable targets, particularly in cancer therapy, while emphasizing the urgent need to discover more E3 ligase recruiters to optimize targeted protein degradation.

This study found that a novel proniosomal gel formulation of CoQ10 improved antioxidant levels and provided better skin protection against UV radiation compared to a conventional CoQ10 gel in animal models.

This study suggests that pretreatment with a PPAR-γ modulator may prevent damage to hair follicle stem cells caused by a chemotherapy metabolite, potentially offering a strategy to mitigate permanent chemotherapy-induced alopecia.