Safety Profile of CAP7.1 Obtained During Phase I Trial in Adult Patients with Refractory Malignancies

    January 2016 in “ Refubium (Universitätsbibliothek der Freien Universität Berlin) ”
    P. Mehlitz
    TLDR CAP7.1 is generally safe at 200 mg/m²/day, but can cause fatigue, nausea, hair loss, fever, and blood-related issues.
    The Phase I trial of CAP7.1, a prodrug of etoposide, involved 19 patients with refractory solid malignancies to assess its safety profile, dose-limiting toxicities, and pharmacokinetics. Patients received doses ranging from 45 mg/m²/day to 200 mg/m²/day. The most common non-hematological adverse events were fatigue, nausea, alopecia, and fever, with over 90% being grade 1 or 2. Hematological adverse events were dose-dependent, with neutropenic fever as the main dose-limiting toxicity. The maximum tolerated dose was between 150 and 200 mg/m²/day, and the recommended phase II dose was 200 mg/m²/day. The safety profile was similar to other topoisomerase inhibitors, with myelosuppression as the primary dose-limiting toxicity.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Shedding again after 6 months of great results.

      in Minoxidil  15 upvotes 1 year ago
      A user experienced shedding after 7 months on Fin/Min spray despite good results and no change in treatment. Other users noted similar experiences and mentioned that shedding periods can be normal.

      community My experience with rosemary oil

      in Product  42 upvotes 3 years ago
      The user's experience with rosemary oil as a hair loss treatment and its effectiveness; they discuss other treatments such as finasteride, minoxidil, and RU58841; there is also discussion of combining oils like peppermint oil, zix, and dermapen.

      community Could you tell this is a hair system?

      in Technology  307 upvotes 3 years ago
      A user who was losing their hair and found an effective solution; they asked for opinions on it and discussed treatments such as Minoxidil, Finasteride, and RU58841, as well as SMP.

      community 11 months on fin only. Regrowth + thickness

      in Progress Pictures  572 upvotes 2 years ago
      A user reported hair regrowth and increased thickness after 11 months using finasteride 1mg, taken 3-4 times a week, with noticeable improvement starting around the third or fourth month. No side effects were mentioned, and the user is considering reducing the dosage to find the minimum needed to maintain results.

    Similar Research

    5 / 1000+ results