333 citations
,
February 2010 in “Cell Stem Cell” This review discusses experimental data, technologies, and genetic factors related to stem cell niches, highlighting their role in tissue regeneration and diseases, but reports no new results.
23 citations
,
April 2021 in “Journal of Clinical Medicine” This review compiles existing data on frontal fibrosing alopecia and highlights the promise of 5-alpha reductase inhibitors as a treatment option, while noting the need for clarity on its cause and progression.
March 2024 in “International journal of molecular sciences” In this study on Angora rabbits, researchers identified genetic factors influencing wool fiber diameter by analyzing hair follicle proteins, highlighting keratin family members and other proteins as key contributors to fiber differences between coarse and fine wool.
191 citations
,
December 2003 in “Journal of Investigative Dermatology” Male pattern baldness is largely genetic, linked to the androgen receptor gene, and may relate to certain health issues.
In this study with mice, simultaneous inactivation of Smad4 and PTEN genes led to rapid development of invasive forestomach squamous cell carcinomas, mirroring human esophageal SCCs.
In this study, the deletion of Smad4 and PTEN genes in mice was associated with rapid and invasive squamous cell carcinoma formation in the forestomach, modeling human esophageal cancer progression.
5 citations
,
August 2016 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers identified over 250 new genetic loci linked to severe male pattern baldness, and developed a prediction algorithm that could accurately differentiate between those with severe and no hair loss.
June 2020 in “Zenodo (CERN European Organization for Nuclear Research)” This study analyzed pediatric and adult patients with antibody deficiencies at a PID center, finding frequent severe infections and genetic mutations, with treatment primarily involving IVIG replacement therapy.
9 citations
,
January 2023 in “Journal of the European Academy of Dermatology and Venereology” This study suggests that genetic overlap between alopecia areata and major depressive disorder may be limited to the MHC region, highlighting the need for further research.
2 citations
,
April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This article discusses the MendelVar webserver, which integrates Mendelian disease data with GWAS findings to prioritize candidate genes for complex traits and reports no new experimental results.
4 citations
,
May 2021 in “Journal of The American Academy of Dermatology” This study found no significant genetic correlations between male pattern baldness and COVID-19 outcomes, suggesting that shared genetic factors may not explain the reported association.
1 citations
,
March 2025 in “Skin Appendage Disorders” Healthcare access for alopecia areata in the USA is unequal among ethnic groups.
This study utilized the Random Forest Algorithm to create a machine learning model aimed at accurately predicting hair loss by considering complex datasets involving genetic, hormonal, lifestyle, and environmental factors, but specific outcomes were not reported.
247 citations
,
August 2011 in “European Journal of Epidemiology” This article outlines the rationale, design, major findings, and updated objectives of the ongoing Rotterdam Study, without presenting new research data.
5 citations
,
November 2020 in “Forensic Science International Genetics” This study found that using trait prevalence-informed priors may improve the prediction accuracy of appearance traits in Bayesian models, but their application is limited by sparse knowledge on trait prevalence.
April 2025 in “Frontiers in Genetics” This study found that integrating breed-specific BOA and SNP-based models helps reveal the genetic factors involved in thermotolerance traits in beef cattle, enhancing insights into thermoregulation and potentially improving cattle's heat resilience.
March 2025 in “Human Genetics and Genomics Advances” This study found that genetic predictions of male pattern baldness from European populations do not generalize well to African populations, highlighting significant differences in genetic architecture between them.
21 citations
,
January 2018 in “PLoS Genetics” This study found that certain keratin gene mutations associated with pachyonychia congenita are linked to altered enamel structure and increased risk of dental caries.
188 citations
,
January 2022 in “PubMed” This review discusses recent advancements in congenital adrenal hyperplasia research, including improved diagnostic techniques, alternative treatments, and insights from long-term outcome data, but it reports no new clinical results.
133 citations
,
January 2009 in “Nature” This study identified gene expression patterns in a mouse model that may influence tumor susceptibility and tissue functions related to inflammation and cell proliferation, highlighting Lgr5 and the vitamin D receptor as key regulators.
116 citations
,
January 1957 in “Australian Journal of Agricultural Research” This study analyzed skin specimens from Australian Merino ewes to estimate hair follicle properties across different strains, providing baseline data essential for future genetic studies on fleece structure, but reported no new conclusions.
89 citations
,
October 1996 in “Dermatologic Clinics” This review discusses androgenetic alopecia and alopecia areata through a systems biology lens, emphasizing the role of multi-omics data integration to explore molecular mechanisms and potential therapeutic strategies, but offers no new clinical results.
43 citations
,
December 2020 in “PLOS Genetics” This study used a new statistical approach, PLACO, to identify several novel shared genetic regions associated with both Type 2 Diabetes and Prostate Cancer in two large GWAS datasets.
18 citations
,
April 2013 in “Inflammatory Bowel Diseases” This review discusses the various potential causes of hair loss in patients with inflammatory bowel disease, including telogen effluvium from disease flares, but provides no prevalence data; the authors outline a practical assessment and management approach.
3 citations
,
August 2021 in “Veterinary dermatology” This review discusses the biology and pathology of hair growth, exploring novel therapies like sublingual minoxidil and Janus kinase inhibitors, but reports no new clinical data.
1 citations
,
March 2023 in “Nutrients” This joint consensus statement from several Polish professional associations discusses strategies for improving obesity treatment and enhancing primary care's role in managing obesity, with no new empirical data reported.
1 citations
,
December 2013 in “Journal of Evolution of Medical and Dental Sciences” This historical review examines the diagnostic and etiological understanding of alopecia areata, emphasizing the evolution of theories and the impact of immunological data, while providing no new clinical results.
1 citations
,
July 2013 in “Hair transplant forum international” This abstract lacks results; it aims to understand hair follicle regulation mechanisms but does not report specific findings or data.
March 2026 in “Archives of Dermatological Research” People with androgenetic alopecia may have a higher genetic risk for cardiovascular diseases.
November 2025 in “Cancers” This study conducted a meta-analysis and found that men with both frontal and vertex male pattern baldness have a slightly increased risk of developing prostate cancer, though most data was from Caucasian populations and effect modification by genetic variations was not assessed.