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Glossary Genetic Data

information about an individual's DNA sequence and genetic traits

Genetic Data refers to information about an individual's DNA, which includes the sequence of nucleotides (adenine, thymine, cytosine, and guanine) that make up their genes. This data can reveal insights into a person's hereditary traits, potential health risks, and predispositions to certain conditions, such as alopecia. It is also known as Genomic Data and is crucial for research in genetics, personalized medicine, and understanding biological processes.

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research Predicting Hair Loss with AI: A Deep Learning Framework Combining Genetic and Scalp Health Data

2 citations , January 2024

In this study, researchers proposed a deep learning approach combining genetic, hormonal, scalp health, and lifestyle data to predict hair loss, employing CNNs for image analysis and RNNs for modeling data over time, although specific results are not reported.

research Genetic prediction of male pattern baldness based on large independent datasets

3 citations , November 2022 in “European Journal of Human Genetics”

This study developed new genetic prediction models for male pattern baldness with improved accuracy by utilizing a large set of markers and independent datasets, making them the most reliable available for this trait.

research Genetic variants in androgenetic alopecia: insights from scalp RNA sequencing data

August 2024 in “Archives of Dermatological Research”

Certain genetic variants and pathways are linked to hair loss.

Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data

research Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data

7 citations , July 2018 in “Journal of Investigative Dermatology”

This article reviews the genetic research on male androgenetic alopecia, highlighting that over 300 associated risk variants have been identified, with unclear mechanisms of action.

research Human hair production by scalp samples grafted onto nude mice. Biochemical data on normal human hair and the genetic defect trichothiodystrophy

2 citations , July 1994 in “Journal of Dermatological Science”

This study found that a laboratory model using nude mice can produce human hair follicles with amino acid compositions resembling both normal and trichothiodystrophy-affected human scalp hair over extended periods.

research Generic Development of Topical Dermatologic Products: Formulation Development, Process Development, and Testing of Topical Dermatologic Products

188 citations , October 2012 in “The AAPS Journal”

This review discusses strategies for developing semi-solid topical generic products to match the quality of reference-listed drugs, using concepts like quality by design and reverse-engineering, but reports no new results.

Phenotypic Heterogeneity in Human Genetic Diseases: Ultrasensitivity-Mediated Threshold Effects as a Unifying Molecular Mechanism

research Phenotypic heterogeneity in human genetic diseases: ultrasensitivity-mediated threshold effects as a unifying molecular mechanism

July 2023 in “Journal of Biomedical Science”

In this review, the authors emphasize that phenotypic heterogeneity in genetic systems and human diseases is influenced by stochastic fluctuation and network topology, proposing that ultrasensitivity and threshold effects explain this variability, which may inform strategies for preventing and treating genetic diseases.

Biological Insights from Self-Perceived Facial Aging Data of the UK Biobank Participants

research Biological insights from self-perceived facial aging data of the UKBB participants

2 citations , September 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study utilized UK Biobank data to identify genetic factors associated with self-perceived facial aging, highlighting significant roles for skin pigmentation, immune pathways, and extracellular matrix genes.

research Transforming 300 billion points of data into diagnostics, therapeutics and new insights into disease

June 2013 in “The mental health clinician”

This review discusses Dr. Atul Butte's lecture on transforming vast data sets into drug discovery insights and highlights the importance of merging clinical, molecular, and environmental data for personalized medicine, but it reports no new clinical results.

research Integrative analysis of Iso-Seq and RNA-seq data reveals transcriptome complexity and differential isoform in skin tissues of different hair length Yak

5 citations , May 2024 in “BMC Genomics”

This study analyzed the transcriptome of the Tianzhu white yak, identifying differential transcripts that shed light on the molecular mechanisms influencing hair length growth variation in this species.

research From the Microscopic Sweat Gland to Large Datasets: The Power of Quantitative Traits in Dermatology

April 2024 in “Journal of Investigative Dermatology”

This study identified three new genetic loci linked to sweat gland density in a GWAS involving 6,210 Han Chinese individuals, highlighting potential targets for understanding conditions like anhidrosis and hyperhidrosis and emphasizing the use of quantitative traits in genetic dermatology research.

research Prediction of male-pattern baldness from genotypes

37 citations , October 2015 in “European Journal of Human Genetics”

This study found that a genetic model using SNPs can predict early-onset male-pattern baldness with moderate accuracy, which may assist in decisions about interventions.

research Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch

5 citations , March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that Piezo2 channels are primarily located on sensory axon membranes in mechanosensory end organs, supporting a model where mechanical stimuli activate Aβ RA-LTMR neurons via axon protrusions.

Relationship of Hypothyroidism with Alopecia Areata and Androgenetic Alopecia: Insights from a Two-Sample Mendelian Randomization Study

research Relationship of Hypothyroidism with Alopecia Areata and Androgenetic Alopecia: Insights from a Two-Sample Mendelian Randomization Study

August 2024 in “Clinical Cosmetic and Investigational Dermatology”

This study investigates the potential causal relationship between hypothyroidism and hair loss conditions like alopecia areata and androgenetic alopecia, noting that previous studies have reported inconsistent findings. Results are not yet detailed.

research Exploring the Relationship Between Immune Cells and Non-Scarring Hair Loss: A Mendelian Randomization Study

July 2024 in “Clinical Cosmetic and Investigational Dermatology”

Certain immune cells are linked to non-scarring hair loss, suggesting potential for immune-targeted treatments.

Utilizing SNP Association Analysis as a Prospective Approach for Personalizing Androgenetic Alopecia Treatment

research Utilising SNP Association Analysis as a Prospective Approach for Personalising Androgenetic Alopecia Treatment

March 2024 in “Dermatology and therapy (Internet)”

This study identified eight genetic markers associated with androgenetic alopecia, suggesting that these SNPs could influence individualized therapeutic responses and highlight the need for personalized treatment strategies.

research Splitting Hairs: Evaluating the Origin of Human Nakedness

March 2023 in “Journal of Student Research”

This study indicates that the thermoregulatory hypothesis is most likely the main factor behind the evolution of hairlessness in humans.

research Understanding the Molecular Landscape of Alopecia Areata: Key Genes, Regulatory Networks, and Therapeutic Targets

June 2026 in “Health Science Reports”

This study examined the genetic basis of alopecia areata by analyzing gene expression differences between patients and healthy controls, identifying critical pathways, hub genes, transcription factors, and miRNAs implicated in the disease, and suggesting potential targets for treatment.

research Prioritizing Susceptibility Genes for the Prognosis of Male-pattern Baldness with Transcriptome-wide Association Study

January 2024 in “Research Square (Research Square)”

This study identified robust susceptibility genes and potential drug candidates for male-pattern baldness, providing insights into the condition's molecular mechanisms.

research Indian Hair

May 2026

This study consolidates information on the unique structural and functional biology of Indian hair, reporting distinct scalp microbial ecology and trichoscopic parameters, which are important for diagnosing and treating hair conditions in Indian populations.

research Genetic prediction of male pattern baldness

133 citations , February 2017 in “PLoS Genetics”

In this study, researchers used genetic data from over 52,000 men to identify over 250 genetic loci associated with severe hair loss and developed a predictive algorithm for determining hair loss risk.

Clinical-Exome Sequencing Unveils the Genetic Landscape of Polycystic Ovarian Syndrome Focusing on Lean and Obese Phenotypes: Implications for Cost-Effective Diagnosis and Personalized Treatment

research Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment

13 citations , October 2024 in “Scientific Reports”

In this study using data from young women in West Bengal, India, the researchers identified that leptin signaling impairment, insulin resistance, and specific gene mutations significantly contribute to PCOS, with obesity commonly manifesting in affected individuals.

research Transcriptome meta-analysis reveals the hair genetic rules in six animal breeds and genes associated with wool fineness

10 citations , June 2024 in “Frontiers in Genetics”

This study analyzed RNA-seq data from various animal breeds and suggested that similar molecular mechanisms may underlie wool fineness in different sheep breeds. Researchers identified 32 candidate genes related to hair follicle regulation, providing insights for molecular breeding and evolutionary studies.

research Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens

2 citations , February 2025 in “Poultry Science”

In this study, researchers investigated the genetic basis of the feathered foot trait in Guangxi native chickens and found that the gene TBX5 plays a critical role, suggesting it affects feather formation by regulating the proliferation and migration of dermal fibroblasts.

research Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men

January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that genetic predictions of male pattern baldness derived from European data do not accurately predict baldness in African populations, highlighting significant continental differences in genetic architecture and evolutionary history.

Diverse Northern Asian and Jomon-Related Genetic Structure Discovered Among Socially Complex Three Kingdoms Period Gaya Region Koreans

research Diverse northern Asian and Jomon-related genetic structure discovered among socially complex Three Kingdoms period Gaya region Koreans

2 citations , October 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study reported the first paleogenomic data from Korea, revealing genetic diversity in ancient Koreans from the Gimhae region, with evidence of admixture between northern-Chinese Iron Age populations and Japanese-Jomon-related ancestry.

research An overview of the genetic aspects of hair loss and its connection with nutrition

49 citations , October 2022 in “PubMed”

This review examines alopecia, its causes, the impact of micronutrients, and the role of the Mediterranean diet, noting conflicting data and a need for more research on diet's effect on hair loss.

research Exploring the possibility of predicting human head hair greying from DNA using whole-exome and targeted NGS data

37 citations , August 2020 in “BMC Genomics”

This study found that while genetic variants contribute minimally to predicting hair greying in a Polish population, age remains the primary predictor, underscoring the complexity of hair greying as a genetic trait.

research Data Sheet 1_A partially automated method for DNA extraction from marmoset hair follicles to avoid blood chimerism.docx

September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

This study developed a partially automated protocol utilizing hair follicles for DNA extraction in marmosets, achieving reliable whole genome sequencing with low chimerism, offering an efficient alternative to blood for genetic studies in non-human primates.

research Real-World Safety Profile of Generic Palbociclib in Hormone Receptor–Positive, HER2-Negative Metastatic Breast Cancer: A Prospective Observational Study in Iraq”

June 2026 in “Journal of cancer research updates”

This study conducted in an Iraqi oncology setting found generic Palbociclib to have a safety profile consistent with previous data, with observed side effects including high rates of neutropenia and anemia, particularly among patients receiving it with Fulvestrant.