Male Hair Loss – What Our Genes Reveal

February 2024 in “ BIOspektrum ”

Sabrina K. Henne, Markus M. Nöthen, Markus M. Nöthen

male-pattern hair loss MPHL genetic causes biological causes heritable molecular genetic studies

TLDR Genetic research may lead to better ways to predict and treat male-pattern hair loss.

The document discusses the genetic and biological causes of male-pattern hair loss (MPHL), a condition that affects up to 80% of European men. The condition is highly heritable and current treatment options are limited, which underscores the need for a better understanding of its biological causes. Recent molecular genetic studies have provided significant insights into these causes. The findings from these studies have the potential to improve prediction and treatment of hair loss.

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Research cited in this study

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research Analysis of 72,469 UK Biobank Exomes Links Rare Variants to Male-Pattern Hair Loss

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Male Hair Loss – What Our Genes Reveal

Research cited in this study

research Analysis of 72,469 UK Biobank Exomes Links Rare Variants to Male-Pattern Hair Loss

research Short Anagen Hair Syndrome: Association With Mono- and Biallelic Variants in WNT10A and a Genetic Overlap With Male Pattern Hair Loss

research Male-Pattern Hair Loss: Comprehensive Identification of the Associated Genes as a Basis for Understanding Pathophysiology

research Mapping of Cis-Acting Expression Quantitative Trait Loci in Human Scalp Hair Follicles

research Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies

research Insights into Male Androgenetic Alopecia: Differential Gene Expression Profiling of Plucked Hair Follicles and Integration with Genetic Data

research Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness

research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

research Scratching the Surface of Skin Development

research Towards a Molecular Understanding of Hair Loss and Its Treatment

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